Malaria biology and disease pathogenesis: insights for new treatments

LH Miller, HC Ackerman, X Su, TE Wellems - Nature medicine, 2013 - nature.com
Plasmodium falciparum malaria, an infectious disease caused by a parasitic protozoan,
claims the lives of nearly a million children each year in Africa alone and is a top public …

Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1‐based vaccines to prevent it

AR Jensen, Y Adams, L Hviid - Immunological reviews, 2020 - Wiley Online Library
Malaria, a mosquito‐borne infectious disease caused by parasites of the genus Plasmodium
continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites …

Severe malaria is associated with parasite binding to endothelial protein C receptor

L Turner, T Lavstsen, SS Berger, CW Wang… - Nature, 2013 - nature.com
Sequestration of Plasmodium falciparum-infected erythrocytes in host blood vessels is a key
triggering event in the pathogenesis of severe childhood malaria, which is responsible for …

Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season

CM Andrade, H Fleckenstein, R Thomson-Luque… - Nature Medicine, 2020 - nature.com
The dry season is a major challenge for Plasmodium falciparum parasites in many malaria
endemic regions, where water availability limits mosquito vectors to only part of the year …

Variant surface antigens of Plasmodium falciparum and their roles in severe malaria

M Wahlgren, S Goel, RR Akhouri - Nature Reviews Microbiology, 2017 - nature.com
Proliferation and differentiation inside erythrocytes are important steps in the life cycle of
Plasmodium spp. To achieve these, the parasites export polypeptides to the surface of …

Malaria immunity in man and mosquito: insights into unsolved mysteries of a deadly infectious disease

PD Crompton, J Moebius, S Portugal… - Annual review of …, 2014 - annualreviews.org
Malaria is a mosquito-borne disease caused by parasites of the obligate intracellular
Apicomplexa phylum the most deadly of which, Plasmodium falciparum, prevails in Africa …

[HTML][HTML] Investigating the pathogenesis of severe malaria: a multidisciplinary and cross-geographical approach

SC Wassmer, TE Taylor, PK Rathod… - The American journal …, 2015 - ncbi.nlm.nih.gov
More than a century after the discovery of Plasmodium spp. parasites, the pathogenesis of
severe malaria is still not well understood. The majority of malaria cases are caused by …

[HTML][HTML] Naturally Acquired Humoral Immunity Against Plasmodium falciparum Malaria

SJ Gonzales, RA Reyes, AE Braddom… - Frontiers in …, 2020 - frontiersin.org
Malaria remains a significant contributor to the global burden of disease, with around 40% of
the world's population at risk of Plasmodium infections. The development of an effective …

[HTML][HTML] Structure-guided identification of a family of dual receptor-binding PfEMP1 that is associated with cerebral malaria

F Lennartz, Y Adams, A Bengtsson, RW Olsen… - Cell host & …, 2017 - cell.com
Cerebral malaria is a deadly outcome of infection by Plasmodium falciparum, occurring
when parasite-infected erythrocytes accumulate in the brain. These erythrocytes display …

New insights into malaria pathogenesis

CA Moxon, MP Gibbins, D McGuinness… - Annual Review of …, 2020 - annualreviews.org
Malaria remains a major public health threat in tropical and subtropical regions across the
world. Even though less than 1% of malaria infections are fatal, this leads to about 430,000 …