The PfEMP1 family of surface proteins is central for Plasmodium falciparum virulence and
must retain the ability to bind to host receptors while also diversifying to aid immune evasion …

Cerebral malaria (CM) is a deadly complication of Plasmodium falciparum infection, but
specific interactions involved in cerebral homing of infected erythrocytes (IEs) are poorly …

In malaria-naïve individuals, Plasmodium falciparum infection results in high levels of
parasite-infected red blood cells (iRBCs) that trigger systemic inflammation and fever …

Sequestration of Plasmodium falciparum‐infected erythrocytes (IE) within the brain
microvasculature is a hallmark of cerebral malaria (CM). Using a microchannel flow …

Infections with Plasmodium falciparum and Plasmodium vivax cause over 600,000 deaths
each year, concentrated in Africa and in young children, but much of the world's population …

Brain swelling is a major predictor of mortality in pediatric cerebral malaria (CM). However,
the mechanisms leading to swelling remain poorly defined. Here, we combined …

Cerebral malaria (CM) affects children and adults, but brain swelling is more severe in
children. To investigate features associated with brain swelling in malaria, we performed …

The var gene family of the human malaria parasite Plasmodium falciparum encode proteins
that are crucial determinants of both pathogenesis and immune evasion and are highly …

Cerebral Plasmodium falciparum malaria is characterized by adhesion of infected
erythrocytes (IEs) to the cerebral microvasculature. This has been linked to parasites …

ABSTRACT Intercellular adhesion molecule 1 (ICAM-1) and the endothelial protein C
receptor (EPCR) are candidate receptors for the deadly complication cerebral malaria …