Plasmodium falciparum adapts its investment into replication versus transmission according to the host environment
The malaria parasite life cycle includes asexual replication in human blood, with a
proportion of parasites differentiating to gametocytes required for transmission to …
proportion of parasites differentiating to gametocytes required for transmission to …
Severe adult malaria is associated with specific PfEMP1 adhesion types and high parasite biomass
The interplay between cellular and molecular determinants that lead to severe malaria in
adults is unexplored. Here, we analyzed parasite virulence factors in an infected adult …
adults is unexplored. Here, we analyzed parasite virulence factors in an infected adult …
Biophysical and biomolecular interactions of malaria-infected erythrocytes in engineered human capillaries
C Arakawa, C Gunnarsson, C Howard, M Bernabeu… - Science …, 2020 - science.org
Microcirculatory obstruction is a hallmark of severe malaria, but mechanisms of parasite
sequestration are only partially understood. Here, we developed a robust three-dimensional …
sequestration are only partially understood. Here, we developed a robust three-dimensional …
The role of PfEMP1 adhesion domain classification in Plasmodium falciparum pathogenesis research
JD Smith - Molecular and biochemical parasitology, 2014 - Elsevier
The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family has a key role
in parasite survival, transmission, and virulence. PfEMP1 are exported to the erythrocyte …
in parasite survival, transmission, and virulence. PfEMP1 are exported to the erythrocyte …
EPCR and malaria severity: the center of a perfect storm
M Bernabeu, JD Smith - Trends in parasitology, 2017 - cell.com
Severe malaria due to Plasmodium falciparum infection causes nearly half a million deaths
per year. The different symptomatology and disease manifestations among patients have …
per year. The different symptomatology and disease manifestations among patients have …
Plasmodium falciparum var genes expressed in children with severe malaria encode CIDRα1 domains
Most severe Plasmodium falciparum infections are experienced by young children. Severe
symptoms are precipitated by vascular sequestration of parasites expressing a particular …
symptoms are precipitated by vascular sequestration of parasites expressing a particular …
The Severity of Plasmodium falciparum Infection Is Associated with Transcript Levels of var Genes Encoding Endothelial Protein C Receptor-Binding P. falciparum …
By attaching infected erythrocytes to the vascular lining, Plasmodium falciparum parasites
leave blood circulation and avoid splenic clearance. This sequestration is central to …
leave blood circulation and avoid splenic clearance. This sequestration is central to …
Parasites causing cerebral falciparum malaria bind multiple endothelial receptors and express EPCR and ICAM-1-binding PfEMP1
N Tuikue Ndam, A Moussiliou… - The Journal of …, 2017 - academic.oup.com
Background. Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) mediates
the binding and accumulation of infected erythrocytes (IE) to blood vessels and tissues …
the binding and accumulation of infected erythrocytes (IE) to blood vessels and tissues …
Pathogenic CD8+ T cells in experimental cerebral malaria
SW Howland, C Claser, CM Poh, SY Gun… - Seminars in …, 2015 - Springer
Cerebral malaria (CM) is one the major complications occurring during malaria infection.
The mechanisms leading to this syndrome are still not completely understood. Although it is …
The mechanisms leading to this syndrome are still not completely understood. Although it is …
The Plasmodium falciparum transcriptome in severe malaria reveals altered expression of genes involved in important processes including surface antigen–encoding …
Within the human host, the malaria parasite Plasmodium falciparum is exposed to multiple
selection pressures. The host environment changes dramatically in severe malaria, but the …
selection pressures. The host environment changes dramatically in severe malaria, but the …