Diverse functional outcomes of Plasmodium falciparum ligation of EPCR: potential implications for malarial pathogenesis
MR Gillrie, M Avril, AJ Brazier, SP Davis… - Cellular …, 2015 - Wiley Online Library
P lasmodium falciparum‐infected erythrocytes (IRBC) expressing the domain cassettes (DC)
8 and 13 of the cytoadherent ligand P. falciparum erythrocyte membrane protein 1 adhere to …
8 and 13 of the cytoadherent ligand P. falciparum erythrocyte membrane protein 1 adhere to …
Antibody Targets on the Surface of Plasmodium falciparum–Infected Erythrocytes That Are Associated With Immunity to Severe Malaria in Young Children
Abstract Background Sequestration of Plasmodium falciparum–infected erythrocytes (IEs) in
the microvasculature contributes to pathogenesis of severe malaria in children. This …
the microvasculature contributes to pathogenesis of severe malaria in children. This …
CD36 and malaria: friends or foes? A decade of data provides some answers
The past 10 years have generated new insights into the complex interaction between CD36
(cluster of differentiation 36) and malaria. These range from the crystallization of the CD36 …
(cluster of differentiation 36) and malaria. These range from the crystallization of the CD36 …
Expression of the Domain Cassette 8 Plasmodium falciparum Erythrocyte Membrane Protein 1 Is Associated with Cerebral Malaria in Benin
Background Plasmodium falciparum erythrocyte membrane protein-1 (Pf EMP-1) is a highly
polymorphic adherence receptor expressed on the surface of infected erythrocytes. Based …
polymorphic adherence receptor expressed on the surface of infected erythrocytes. Based …
A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo …
C Andradi-Brown, JS Wichers-Misterek, H von Thien… - Elife, 2024 - elifesciences.org
The pathogenesis of severe Plasmodium falciparum malaria involves cytoadhesive
microvascular sequestration of infected erythrocytes, mediated by P. falciparum erythrocyte …
microvascular sequestration of infected erythrocytes, mediated by P. falciparum erythrocyte …
IgG antibodies to endothelial protein C receptor-binding cysteine-rich interdomain region domains of Plasmodium falciparum erythrocyte membrane protein 1 are …
L Turner, T Lavstsen, BP Mmbando… - Infection and …, 2015 - Am Soc Microbiol
Severe malaria syndromes are precipitated by Plasmodium falciparum parasites binding to
endothelial receptors on the vascular lining. This binding is mediated by members of the …
endothelial receptors on the vascular lining. This binding is mediated by members of the …
Meta-analysis of Plasmodium falciparum var Signatures Contributing to Severe Malaria in African Children and Indian Adults
The clinical presentation of severe Plasmodium falciparum malaria differs between children
and adults, but the mechanistic basis for this remains unclear. Contributing factors to …
and adults, but the mechanistic basis for this remains unclear. Contributing factors to …
Stuck in a rut? Reconsidering the role of parasite sequestration in severe malaria syndromes
AJ Cunnington, EM Riley, M Walther - Trends in parasitology, 2013 - cell.com
Severe malaria defines individuals at increased risk of death from their infection. Proposed
pathogenic mechanisms include parasite sequestration, inflammation, and endothelial …
pathogenic mechanisms include parasite sequestration, inflammation, and endothelial …
Protein C system defects inflicted by the malaria parasite protein PfEMP1 can be overcome by a soluble EPCR variant
JEV Petersen, EAM Bouwens, I Tamayo… - Thrombosis and …, 2015 - thieme-connect.com
The Endothelial Protein C receptor (EPCR) is essential for the anticoagulant and
cytoprotective functions of the Protein C (PC) system. Selected variants of the malaria …
cytoprotective functions of the Protein C (PC) system. Selected variants of the malaria …
Patterns of heterochromatin transitions linked to changes in the expression of Plasmodium falciparum clonally variant genes
L Michel-Todó, C Bancells, N Casas-Vila… - Microbiology …, 2023 - Am Soc Microbiol
The survival of malaria parasites in the changing human blood environment largely depends
on their ability to alter gene expression by epigenetic mechanisms. The active state of …
on their ability to alter gene expression by epigenetic mechanisms. The active state of …