The burden of human disease lies predominantly in polygenic diseases. Since the early
2000s, genome-wide association studies (GWAS) have identified genetic variants and loci …

With the growing number of genetic association studies, the genotype-phenotype atlas has
become increasingly more complex, yet the functional consequences of most disease …

Microglia are resident myeloid cells in the central nervous system (CNS) with a unique
developmental origin, playing essential roles in developing and maintaining the CNS …

Age-related macular degeneration (AMD) is one of the most common causes of visual
impairment in the elderly, with a complex and still poorly understood etiology. Whole …

Sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 (SVEP1) is an
extracellular matrix protein that causally promotes vascular disease and associates with …

Background Many observational epidemiology studies discovered that kidney cancer and
impaired kidney function have a bidirectional relationship. However, it remains unclear …

Aim To examine the ability of serum proteins in predicting future heart failure (HF) events,
including HF with reduced or preserved ejection fraction (HFrEF or HFpEF), in relation to …

Objectives This study aims to identify circulating proteins that are causally associated with
osteoarthritis (OA)-related traits through Mendelian randomisation (MR)-based analytical …

Background: The TOPCAT trial (Treatment of Preserved Cardiac Function Heart Failure With
an Aldosterone Antagonist Trial) suggested clinical benefits of spironolactone treatment …

Aims/hypothesis Genetic predisposition to type 2 diabetes is well-established, and genetic
risk scores (GRS) have been developed that capture heritable liabilities for type 2 diabetes …