The microenvironment characteristics of solid tumors, renowned as barriers that harshly
impeded many drug-delivery approaches, were precisely studied, investigated, categorized …

Resistance to cancer therapy remains a major challenge in clinical oncology. Although the
initial treatment phase is often successful, eventual resistance, characterized by tumour …

Abstract CD4+ CD25+ regulatory T cells are involved in the prevention of autoimmune
diseases and in tumor-induced tolerance. We previously demonstrated in tumor-bearing …

Metronomic chemotherapy describes the close, regular administration of chemotherapy
drugs at less-toxic doses over prolonged periods of time. In 2015, the results of randomized …

The contribution of bone marrow–derived circulating endothelial progenitor cells (CEPs) to
tumor angiogenesis has been controversial, primarily because of their low numbers in blood …

Angiogenesis is a hallmark of tumor development and metastasis and is now a validated
target for cancer treatment. However, the survival benefits of antiangiogenic drugs have thus …

Vascular endothelial cells have been identified as a critical component of the neural stem
cell niche, raising the possibility that brain tumor stem-like cells (TSLC) may also rely on …

Objective—To determine survival time for dogs with splenic hemangiosarcoma treated with
splenectomy alone, identify potential prognostic factors, and evaluate the efficacy of …

Background: Continuous administration of low doses of cyclophosphamide and standard
doses of cyclooxygenase‐inhibiting drugs has been shown to suppress tumor angiogenesis …

Metronomic antiangiogenic chemotherapy, the prolonged administration of relatively low
drug doses, at close regular intervals with no significant breaks, has been mainly studied at …