Macrophage immunometabolism in inflammatory bowel diseases: from pathogenesis to therapy

X Pan, Q Zhu, LL Pan, J Sun - Pharmacology & therapeutics, 2022 - Elsevier
Inflammatory bowel disease (IBD), comprised of ulcerative colitis and Crohn's disease, is a
chronic relapsing inflammatory disease of the gastrointestinal tract that closely related to …

Nanozyme‐Based Regulation of Cellular Metabolism and Their Applications

Y Wang, X Jia, S An, W Yin, J Huang… - Advanced …, 2024 - Wiley Online Library
Metabolism is the sum of the enzyme‐dependent chemical reactions, which produces
energy in catabolic process and synthesizes biomass in anabolic process, exhibiting high …

An orally-administered nanotherapeutics with carbon monoxide supplying for inflammatory bowel disease therapy by scavenging oxidative stress and restoring gut …

X Zhang, Z Yuan, J Wu, Y He, G Lu, D Zhang, Y Zhao… - ACS …, 2023 - ACS Publications
Traditional drug-based treatments for inflammatory bowel disease (IBD) have significant
limitations due to their potential off-target systemic side-effects. Currently, there is a lack of …

Traditional Chinese medicine active ingredients-based selenium nanoparticles regulate antioxidant selenoproteins for spinal cord injury treatment

S Rao, Y Lin, R Lin, J Liu, H Wang, W Hu… - Journal of …, 2022 - Springer
Abstract Background As Traditional Chinese Medicine (TCM) drugs, Huangqi and Danshen
are always applied in combination for spinal cord injury (SCI) treatment based on the …

[HTML][HTML] Nano-in-micro alginate/chitosan hydrogel via electrospray technology for orally curcumin delivery to effectively alleviate ulcerative colitis

C Zhang, X Wang, M Xiao, J Ma, Y Qu, L Zou, J Zhang - Materials & Design, 2022 - Elsevier
Although nano-systems can promote the cellular internalization, polymeric nanoparticles
(NPs) are easily to be destroyed or eliminated in the gastrointestinal tract, which leads to …

Advances in the treatment of inflammatory bowel disease: Focus on polysaccharide nanoparticulate drug delivery systems

H Hadji, K Bouchemal - Advanced Drug Delivery Reviews, 2022 - Elsevier
The complex pathogenesis of inflammatory bowel disease (IBD) explains the several
hurdles for finding an efficient approach to cure it. Nowadays, therapeutic protocols aim to …

Colon-Targeting Angelica sinensis Polysaccharide Nanoparticles with Dual Responsiveness for Alleviation of Ulcerative Colitis

Y Xu, BW Zhu, R Sun, X Li, D Wu… - ACS Applied Materials & …, 2023 - ACS Publications
Intestinal immune dysfunction and gut microbiota dysbiosis are critically causative factors in
the pathogenesis of ulcerative colitis (UC); however, the current first-line drugs for UC …

Nanocrystalline cellulose modulates dysregulated intestinal barriers in ulcerative colitis

M Wang, R Cha, W Hao, X Jiang - ACS nano, 2023 - ACS Publications
Ulcerative colitis (UC) is a recurrent chronic inflammation of the colon with increasing
incidence and prevalence, which could increase the risk of colorectal cancer. It is urgent to …

Cuproptosis‐Driven Enhancement of Thermotherapy by Sequentially Response Cu2‐xSe via Copper Chemical Transition

L Chan, Y Liu, M Chen, Y Su, J Guo… - Advanced Functional …, 2023 - Wiley Online Library
Activation of cuproptosis pathway has been reported to hold great potential in the
application of tumor treatment. But the efficacy of cuproptosis seriously limited by the …

The progression of inorganic nanoparticles and natural products for inflammatory bowel disease

Q Li, L Lin, C Zhang, H Zhang, Y Ma, H Qian… - Journal of …, 2024 - Springer
There is a growing body of evidence indicating a close association between inflammatory
bowel disease (IBD) and disrupted intestinal homeostasis. Excessive production of reactive …