Tendon–bone insertion (TBI) injuries, such as anterior cruciate ligament injury and rotator
cuff injury, are the most common soft tissue injuries. In most situations, surgical …

Mesenchymal stem cells (MSCs) have captured great attention in regenerative medicine for
over a few decades by virtue of their differentiation capacity, potent immunomodulatory …

Endothelial malfunction is responsible for impaired angiogenesis in diabetic patients,
thereby causing the delayed healing progress of diabetic wounds. Exosomes or …

Tissue engineering has been an inveterate area in the field of regenerative medicine for
several decades. However, there remains limitations to engineer and regenerate tissues …

The regeneration of bone defects in patients with diabetes mellitus (DM) is remarkably
impaired by hyperglycemia and over-expressed proinflammatory cytokines, proteinases …

Unhealable diabetic wounds need to be addressed with the help of newer, more efficacious
strategies. Exosomes combined with biomaterials for sustained delivery of therapeutic …

In recent years, due to the limitations of the nature of therapeutic agents, many synthetic
nano-delivery systems have emerged to enhance the efficacy of drugs. Extracellular vesicles …

Macrophages (Mφs) are characterized by remarkable plasticity, an essential component of
chronic inflammation. Thus, an appropriate and timely transition from proinflammatory (M1) …

Complexity and difficulties in wound management are pressing concerns that affect patients'
quality of life and may result in tissue infection, necrosis, and loss of local and systemic …

Biomimetic bone regeneration methods which demonstrate both clinical and manufacturing
feasibility, as alternatives to autogenic or allogenic bone grafting, remain a challenge to the …