Epilepsy is well-recognized as a disorder of brain networks. There is a growing body of
research to identify critical nodes within dynamic epileptic networks with the aim to target …

Cognitive functions are increasingly understood to involve coordinated activity patterns
between multiple brain regions, and their disruption by neuropsychiatric disorders is …

Although the etiology of major depressive disorder remains poorly understood, reduced
gamma oscillations is an emerging biomarker. Olfactory bulbectomy, an established model …

Deep brain stimulation (DBS) is a promising neuromodulation therapy, but the
neurophysiological mechanisms of DBS remain unclear. In awake mice, we performed high …

Direct electrical stimulation of the seizure focus can achieve the early termination of epileptic
oscillations. However, direct intervention of the hippocampus, the most prevalent seizure …

Seizures can emerge from multiple or large foci in temporal lobe epilepsy, complicating
focally targeted strategies such as surgical resection or the modulation of the activity of …

The medial septum (MS), as part of the basal forebrain, supports many physiological
functions, from sensorimotor integration to cognition. With often reciprocal connections with …

Direct cortical stimulation has been applied in epilepsy for nearly a century and has
experienced a renaissance, given unprecedented opportunities to probe, excite, and inhibit …

Drug-resistant epilepsy, characterized by ongoing seizures despite appropriate trials of anti-
seizure medications, affects approximately one-third of people with epilepsy. Brain …

Electrical brain stimulation has become an essential treatment option for more than one third
of epilepsy patients who are resistant to pharmacological therapy and are not candidates for …