Anti-amyloid therapies for Alzheimer's disease and the amyloid cascade hypothesis

E Fedele - International journal of molecular sciences, 2023 - mdpi.com
Over the past 30 years, the majority of (pre) clinical efforts to find an effective therapy for
Alzheimer's disease (AD) focused on clearing the β-amyloid peptide (Aβ) from the brain …

[HTML][HTML] Exploring cerebral amyloid angiopathy: Insights into pathogenesis, diagnosis, and treatment

M Cozza, L Amadori, V Boccardi - Journal of the Neurological Sciences, 2023 - Elsevier
Abstract Cerebral Amyloid Angiopathy (CAA) is a neurological disorder characterized by the
deposition of amyloid plaques in the walls of cerebral blood vessels. This condition poses …

Osteocyte-derived sclerostin impairs cognitive function during ageing and Alzheimer's disease progression

T Shi, S Shen, Y Shi, Q Wang, G Zhang, J Lin… - Nature …, 2024 - nature.com
Ageing increases susceptibility to neurodegenerative disorders, such as Alzheimer's
disease (AD). Serum levels of sclerostin, an osteocyte-derived Wnt–β-catenin signalling …

The neurotransmitter puzzle of Alzheimer's: Dissecting mechanisms and exploring therapeutic horizons

M Sharma, P Pal, SK Gupta - Brain Research, 2024 - Elsevier
Alzheimer's Disease (AD) represents a complex interplay of neurological pathways and
molecular mechanisms, with significant impacts on patients' lives. This review synthesizes …

Positive allosteric modulators of SERCA pump restore dendritic spines and rescue long-term potentiation defects in Alzheimer's disease mouse model

A Rakovskaya, A Erofeev, E Vinokurov… - International journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disorder that affects memory formation and
storage processes. Dysregulated neuronal calcium (Ca2+) has been identified as one of the …

Intranasal Drug Delivery by Nanotechnology: Advances in and Challenges for Alzheimer's Disease Management

S Dighe, S Jog, M Momin, S Sawarkar, A Omri - Pharmaceutics, 2023 - mdpi.com
Alzheimer's disease, a progressive neurodegenerative condition, is characterized by a
gradual decline in cognitive functions. Current treatment approaches primarily involve the …

Neurodevelopmental disorders and microcephaly: how apoptosis, the cell cycle, tau and amyloid-β precursor protein APPly

DK Sokol, DK Lahiri - Frontiers in Molecular Neuroscience, 2023 - frontiersin.org
Recent studies promote new interest in the intersectionality between autism spectrum
disorder (ASD) and Alzheimer's Disease. We have reported high levels of Amyloid-β …

Alzheimer's Disease Immunotherapy: Current Strategies and Future Prospects

A Aljassabi, T Zieneldien, J Kim… - Journal of Alzheimer's …, 2024 - content.iospress.com
Alzheimer's disease (AD) is an extremely complex and heterogeneous pathology influenced
by many factors contributing to its onset and progression, including aging, amyloid-beta (Aβ) …

[HTML][HTML] Emerging evidence for the use of Antidiabetic Drugs, glucagon-like peptide 1 receptor agonists, for the treatment of Alzheimer's Disease

IM Colin, LW Szczepanski, AC Gérard… - touchREVIEWS in …, 2023 - ncbi.nlm.nih.gov
From an epidemiological and pathophysiological point of view, Alzheimer's disease (AD)
and type 2 diabetes (T2DM) should be considered'sister'diseases. T2DM significantly …

The performance of plasma phosphorylated tau231 in detecting Alzheimer's disease: A systematic review with meta‐analysis

C Xu, L Zhao, C Dong - European Journal of Neuroscience, 2023 - Wiley Online Library
Cerebrospinal fluid (CSF) phosphorylated tau231 (P‐tau231) is associated with
neuropathological outcomes of Alzheimer's disease (AD). The invasive access of …