[HTML][HTML] Current FDA-approved therapies for high-grade malignant gliomas
JP Fisher, DC Adamson - Biomedicines, 2021 - mdpi.com
The standard of care (SOC) for high-grade gliomas (HGG) is maximally safe surgical
resection, followed by concurrent radiation therapy (RT) and temozolomide (TMZ) for 6 …
resection, followed by concurrent radiation therapy (RT) and temozolomide (TMZ) for 6 …
[HTML][HTML] Glioblastoma treatment modalities besides surgery
Glioblastoma multiforme (GBM) is commonly known as the most aggressive primary CNS
tumor in adults. The mean survival of it is 14 to 15 months, following the standard therapy …
tumor in adults. The mean survival of it is 14 to 15 months, following the standard therapy …
Personalized radiotherapy design for glioblastoma: integrating mathematical tumor models, multimodal scans, and Bayesian inference
Glioblastoma (GBM) is a highly invasive brain tumor, whose cells infiltrate surrounding
normal brain tissue beyond the lesion outlines visible in the current medical scans. These …
normal brain tissue beyond the lesion outlines visible in the current medical scans. These …
The radiosurgery fractionation quandary: single fraction or hypofractionation?
Stereotactic radiosurgery (SRS), typically administered in a single session, is widely
employed to safely, efficiently, and effectively treat small intracranial lesions. However, for …
employed to safely, efficiently, and effectively treat small intracranial lesions. However, for …
[HTML][HTML] Predictive digital twin for optimizing patient-specific radiotherapy regimens under uncertainty in high-grade gliomas
We develop a methodology to create data-driven predictive digital twins for optimal risk-
aware clinical decision-making. We illustrate the methodology as an enabler for an …
aware clinical decision-making. We illustrate the methodology as an enabler for an …
Radiation dose‐enhancement is a potent radiotherapeutic effect of rare‐earth composite nanoscintillators in preclinical models of glioblastoma
AL Bulin, M Broekgaarden, F Chaput… - Advanced …, 2020 - Wiley Online Library
To improve the prognosis of glioblastoma, innovative radiotherapy regimens are required to
augment the effect of tolerable radiation doses while sparing surrounding tissues. In this …
augment the effect of tolerable radiation doses while sparing surrounding tissues. In this …
High dose bystander effects in spatially fractionated radiation therapy
R Asur, KT Butterworth, JA Penagaricano, KM Prise… - Cancer letters, 2015 - Elsevier
Traditional radiotherapy of bulky tumors has certain limitations. Spatially fractionated
radiation therapy (GRID) and intensity modulated radiotherapy (IMRT) are examples of …
radiation therapy (GRID) and intensity modulated radiotherapy (IMRT) are examples of …
[HTML][HTML] Clinical application of MR-Linac in tumor radiotherapy: a systematic review
X Liu, Z Li, Y Yin - Radiation Oncology, 2023 - Springer
Recent years have seen both a fresh knowledge of cancer and impressive advancements in
its treatment. However, the clinical treatment paradigm of cancer is still difficult to implement …
its treatment. However, the clinical treatment paradigm of cancer is still difficult to implement …
Phase II study of bevacizumab, temozolomide, and hypofractionated stereotactic radiotherapy for newly diagnosed glioblastoma
A Omuro, K Beal, P Gutin, S Karimi, DD Correa… - Clinical Cancer …, 2014 - AACR
Purpose: Bevacizumab is associated with decreased vascular permeability that allows for
more aggressive radiotherapy schedules. We conducted a phase II trial in newly diagnosed …
more aggressive radiotherapy schedules. We conducted a phase II trial in newly diagnosed …
[HTML][HTML] Molecular pathways implicated in radioresistance of glioblastoma multiforme: what is the role of extracellular vesicles?
Glioblastoma multiforme (GBM) is a primary brain tumor that is very aggressive, resistant to
treatment, and characterized by a high degree of anaplasia and proliferation. Routine …
treatment, and characterized by a high degree of anaplasia and proliferation. Routine …