Abstract Cyclic GMP-AMP (cGAMP) synthase (cGAS) senses misplaced genomic,
mitochondrial, and microbial double-stranded DNA (dsDNA) to synthesize 2′ 3′-cGAMP …

Background Intracellular DNA-sensing pathway cGAS-STING, inflammasomes and
pyroptosis act as critical natural immune signaling axes for microbial infection, chronic …

We report the results of GUIDANCE-01 (NCT04025593), a randomized, phase II trial of R-
CHOP alone or combined with targeted agents (R-CHOP-X) guided by genetic subtyping of …

Abstract TP53 mutation (TP53 mut) occurs in 10–20% of diffuse large B-cell lymphoma
(DLBCL) cases and serves as an unfavorable biomarker of DLBCL progression. It confers …

Inactivating TP53 mutations leads to a loss of function of p53, but can also often result in
oncogenic gain-of-function (GOF) of mutant p53 (mutp53) proteins which promotes tumor …

Simple Summary Human endogenous retrovirus (HERV) plays important roles in the
development of cancer, and most studies use data from The Cancer Genome Atlas to …

Acute myeloid leukemia (AML) is an aggressive hematologic cancer in adults. Some
patients exhibit restricted T cell infiltration and do not respond to routine treatments. This …

DNA methylation is an important epigenetic mechanism involved in the anti-tumor immune
response, and DNA methyltransferase inhibitors (DNMTi) have achieved impressive …

Simple Summary Diffuse large B-cell lymphoma is a heterogeneous entity comprised of
several distinct biological subtypes. Multiple molecular studies have attempted to classify …

Acute myeloid leukemia (AML) is one of the most threatening hematological malignances.
cGAS-STING pathway plays an important role in tumor immunity and development …