ADAM10 and ADAM17 promote SARS‐CoV‐2 cell entry and spike protein‐mediated lung cell fusion

G Jocher, V Grass, SK Tschirner, L Riepler… - EMBO …, 2022 - embopress.org
The severe‐acute‐respiratory‐syndrome‐coronavirus‐2 (SARS‐CoV‐2) is the causative
agent of COVID‐19, but host cell factors contributing to COVID‐19 pathogenesis remain only …

The interplay between inflammatory pathways and COVID-19: A critical review on pathogenesis and therapeutic options

S Choudhary, K Sharma, O Silakari - Microbial pathogenesis, 2021 - Elsevier
Abstract COVID-19, caused by SARS-CoV-2, emerged as the deadliest outbreak that has
now become a serious health issue to mankind. Activation of inflammatory signaling …

[HTML][HTML] METTL3 regulates viral m6A RNA modification and host cell innate immune responses during SARS-CoV-2 infection

N Li, H Hui, B Bray, GM Gonzalez, M Zeller… - Cell reports, 2021 - cell.com
It is urgent and important to understand the relationship of the widespread severe acute
respiratory syndrome coronavirus clade 2 (SARS-CoV-2) with host immune response and …

Shotgun transcriptome, spatial omics, and isothermal profiling of SARS-CoV-2 infection reveals unique host responses, viral diversification, and drug interactions

D Butler, C Mozsary, C Meydan, J Foox… - Nature …, 2021 - nature.com
In less than nine months, the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-
CoV-2) killed over a million people, including> 25,000 in New York City (NYC) alone. The …

Small molecules in the treatment of COVID-19

S Lei, X Chen, J Wu, X Duan, K Men - Signal transduction and targeted …, 2022 - nature.com
The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …

[HTML][HTML] Circulating mitochondrial DNA is an early indicator of severe illness and mortality from COVID-19

D Scozzi, M Cano, L Ma, D Zhou, JH Zhu… - JCI insight, 2021 - ncbi.nlm.nih.gov
Background Mitochondrial DNA (MT-DNA) are intrinsically inflammatory nucleic acids
released by damaged solid organs. Whether circulating cell-free MT-DNA quantitation could …

Cytokine storm: the primary determinant for the pathophysiological evolution of COVID-19 deterioration

R Chen, Z Lan, J Ye, L Pang, Y Liu, W Wu… - Frontiers in …, 2021 - frontiersin.org
The coronavirus disease 2019 (COVID-19) pandemic caused by the novel severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) is an ongoing major threat to global …

JAK-STAT pathway inhibition and their implications in COVID-19 therapy

S Satarker, AA Tom, RA Shaji, A Alosious… - Postgraduate …, 2021 - Taylor & Francis
As the incidence of COVID-19 increases with time, more and more efforts are made to pave
a way out for the therapeutic strategies to deal with the disease progression. Inflammation …

Oxidative stress status in COVID-19 patients hospitalized in intensive care unit for severe pneumonia. A pilot study

J Pincemail, E Cavalier, C Charlier, JP Cheramy–Bien… - Antioxidants, 2021 - mdpi.com
Background: A key role of oxidative stress has been highlighted in the pathogenesis of
COVID-19. However, little has been said about oxidative stress status (OSS) of COVID-19 …

On inflammatory hypothesis of depression: what is the role of IL-6 in the middle of the chaos?

E Roohi, N Jaafari, F Hashemian - Journal of neuroinflammation, 2021 - Springer
Many patients with major depressive disorder (MDD) are reported to have higher levels of
multiple inflammatory cytokines including interleukin 6 (IL-6). Recent studies both pre …