The UK Biobank imaging enhancement of 100,000 participants: rationale, data collection, management and future directions
TJ Littlejohns, J Holliday, LM Gibson, S Garratt… - Nature …, 2020 - nature.com
UK Biobank is a population-based cohort of half a million participants aged 40–69 years
recruited between 2006 and 2010. In 2014, UK Biobank started the world's largest multi …
recruited between 2006 and 2010. In 2014, UK Biobank started the world's largest multi …
Electronic health records and polygenic risk scores for predicting disease risk
Accurate prediction of disease risk based on the genetic make-up of an individual is
essential for effective prevention and personalized treatment. Nevertheless, to date …
essential for effective prevention and personalized treatment. Nevertheless, to date …
Genetic insights into human cortical organization and development through genome-wide analyses of 2,347 neuroimaging phenotypes
Our understanding of the genetics of the human cerebral cortex is limited both in terms of the
diversity and the anatomical granularity of brain structural phenotypes. Here we conducted a …
diversity and the anatomical granularity of brain structural phenotypes. Here we conducted a …
Toward circuit mechanisms of pathophysiology in depression
T Spellman, C Liston - American Journal of Psychiatry, 2020 - Am Psychiatric Assoc
The search for more effective treatments for depression is a long-standing primary objective
in both psychiatry and translational neuroscience. From initial models centered on …
in both psychiatry and translational neuroscience. From initial models centered on …
Polygenic risk scores in clinical psychology: bridging genomic risk to individual differences
R Bogdan, DAA Baranger… - Annual review of clinical …, 2018 - annualreviews.org
Genomewide association studies (GWASs) across psychiatric phenotypes have shown that
common genetic variants generally confer risk with small effect sizes (odds ratio< 1.1) that …
common genetic variants generally confer risk with small effect sizes (odds ratio< 1.1) that …
A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank
Depression is a leading cause of worldwide disability but there remains considerable
uncertainty regarding its neural and behavioural associations. Here, using non-overlapping …
uncertainty regarding its neural and behavioural associations. Here, using non-overlapping …
Grey and white matter microstructure is associated with polygenic risk for schizophrenia
Recent discovery of approximately 270 common genetic variants associated with
schizophrenia has enabled polygenic risk scores (PRS) to be measured in the population …
schizophrenia has enabled polygenic risk scores (PRS) to be measured in the population …
Thalamic reticular dysfunction as a circuit endophenotype in neurodevelopmental disorders
Diagnoses of behavioral disorders such as autism spectrum disorder and schizophrenia are
based on symptomatic descriptions that have been difficult to connect to mechanism …
based on symptomatic descriptions that have been difficult to connect to mechanism …
Dissecting autism and schizophrenia through neuroimaging genomics
Neuroimaging genomic studies of autism spectrum disorder and schizophrenia have mainly
adopted a 'top-down'approach, beginning with the behavioural diagnosis, and moving down …
adopted a 'top-down'approach, beginning with the behavioural diagnosis, and moving down …
The endocytic membrane trafficking pathway plays a major role in the risk of Parkinson's disease
S Bandres‐Ciga, S Saez‐Atienzar… - Movement …, 2019 - Wiley Online Library
Background PD is a complex polygenic disorder. In recent years, several genes from the
endocytic membrane‐trafficking pathway have been suggested to contribute to disease …
endocytic membrane‐trafficking pathway have been suggested to contribute to disease …