Aging has been linked to several degenerative processes that, through the accumulation of
molecular and cellular damage, can progressively lead to cell dysfunction and organ failure …

Mitochondrial oxidative damage contributes to a range of degenerative diseases.
Consequently, the selective inhibition of mitochondrial oxidative damage is a promising …

Transient or permanent interruption of cerebral blood flow by occlusion of a cerebral artery
gives rise to an ischaemic stroke leading to irreversible damage or dysfunction to the cells …

Alcohol is a well‐established teratogen that can cause variable physical and behavioral
effects on the fetus. The most severe condition in this spectrum of diseases is known as fetal …

Reactive oxygen species (ROS) contain one or more unpaired electrons and are formed as
intermediates in a variety of normal biochemical reactions. However, when generated in …

Mitochondrial dysfunction has long been associated with neurodegenerative disease.
Therefore, mitochondrial protective agents represent a unique direction for the development …

Mitochondria are key cytoplasmic organelles, responsible for generating cellular energy,
regulating intracellular calcium levels, altering the reduction-oxidation potential of cells, and …

Oxidative damage is related to aging and a wide range of human disorders. Mitochondria
are in large part responsible for free radical production and they are also main targets of the …

The ingestion of alcohol/ethanol during pregnancy can result in abnormal fetal development
in both humans and a variety of experimental animal models. Depending on the pattern of …

Extensive literature exists supporting a role for mitochondrial dysfunction and oxidative
damage in the pathogenesis of Alzheimer's disease. Mitochondria are a major source of …