Maternal immune activation and neuroinflammation in human neurodevelopmental disorders

VX Han, S Patel, HF Jones, RC Dale - Nature Reviews Neurology, 2021 - nature.com
Maternal health during pregnancy plays a major role in shaping health and disease risks in
the offspring. The maternal immune activation hypothesis proposes that inflammatory …

Sex and gender in neurodevelopmental conditions

S Bölte, J Neufeld, PB Marschik, ZJ Williams… - Nature Reviews …, 2023 - nature.com
Health-related conditions often differ qualitatively or quantitatively between individuals of
different birth-assigned sexes and gender identities, and/or with different gendered …

Association of birth during the COVID-19 pandemic with neurodevelopmental status at 6 months in infants with and without in utero exposure to maternal SARS-CoV-2 …

LC Shuffrey, MR Firestein, MH Kyle, A Fields… - JAMA …, 2022 - jamanetwork.com
Importance Associations between in utero exposure to maternal SARS-CoV-2 infection and
neurodevelopment are speculated, but currently unknown. Objective To examine the …

Maternal acute and chronic inflammation in pregnancy is associated with common neurodevelopmental disorders: a systematic review

VX Han, S Patel, HF Jones, TC Nielsen… - Translational …, 2021 - nature.com
Inflammation is increasingly recognized as a cause or consequence of common problems of
humanity including obesity, stress, depression, pollution and disease states such as …

Innate immunity at the crossroads of healthy brain maturation and neurodevelopmental disorders

KE Zengeler, JR Lukens - Nature Reviews Immunology, 2021 - nature.com
The immune and nervous systems have unique developmental trajectories that individually
build intricate networks of cells with highly specialized functions. These two systems have …

Maternal-fetal inflammation in the placenta and the developmental origins of health and disease

JA Goldstein, K Gallagher, C Beck, R Kumar… - Frontiers in …, 2020 - frontiersin.org
Events in fetal life impact long-term health outcomes. The placenta is the first organ to form
and is the site of juxtaposition between the maternal and fetal circulations. Most diseases of …

Sex differences in autism spectrum disorder: diagnostic, neurobiological, and behavioral features

A Napolitano, S Schiavi, P La Rosa… - Frontiers in …, 2022 - frontiersin.org
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder with a
worldwide prevalence of about 1%, characterized by impairments in social interaction …

Maternal immune activation by poly I: C as a preclinical model for neurodevelopmental disorders: a focus on autism and schizophrenia

FL Haddad, SV Patel, S Schmid - Neuroscience & Biobehavioral Reviews, 2020 - Elsevier
Maternal immune activation (MIA) in response to a viral infection during early and mid-
gestation has been linked through various epidemiological studies to a higher risk for the …

Maternal inflammation and its ramifications on fetal neurodevelopment

HK Kwon, GB Choi, JR Huh - Trends in immunology, 2022 - cell.com
Exposure to heightened inflammation in pregnancy caused by infections or other
inflammatory insults has been associated with the onset of neurodevelopmental and …

LPS versus Poly I: C model: comparison of long-term effects of bacterial and viral maternal immune activation on the offspring

M Bao, N Hofsink, T Plösch - American Journal of …, 2022 - journals.physiology.org
A prominent health issue nowadays is the COVID-19 pandemic, which poses acute risks to
human health. However, the long-term health consequences are largely unknown and …