IBS 2.0: an upgraded illustrator for the visualization of biological sequences

Y Xie, H Li, X Luo, H Li, Q Gao, L Zhang… - Nucleic Acids …, 2022 - academic.oup.com
The visualization of biological sequences with various functional elements is fundamental
for the publication of scientific achievements in the field of molecular and cellular biology …

3′ UTR heterogeneity and cancer progression

JJ Chan, H Tabatabaeian, Y Tay - Trends in Cell Biology, 2023 - cell.com
The majority of human mRNAs generate alternative 3′ untranslated regions (UTRs)
through various processes, including RNA modifications such as RNA editing, m 6 A …

Advances in the profiling of N6-methyladenosine (m6A) modifications

H Zheng, X Zhang, N Sui - Biotechnology advances, 2020 - Elsevier
Over 160 RNA modifications have been identified, including N 7-methylguanine (m 7 G), N 6-
methyladenosine (m 6 A), and 5-methylcytosine (m 5 C). These modifications play key roles …

M6AREG: m6A-centered regulation of disease development and drug response

S Liu, L Chen, Y Zhang, Y Zhou, Y He… - Nucleic Acids …, 2023 - academic.oup.com
As the most prevalent internal modification in eukaryotic RNAs, N 6-methyladenosine (m6A)
has been discovered to play an essential role in cellular proliferation, metabolic …

[HTML][HTML] Downregulation of circ-ZNF609 promotes heart repair by modulating RNA N6-methyladenosine-modified Yap expression

L Wang, P Yu, J Wang, G Xu, T Wang, J Feng, Y Bei… - Research, 2022 - spj.science.org
Circular RNAs take crucial roles in several pathophysiological processes. The regulatory
role and its underlying mechanisms of circ-ZNF609 in the heart remains largely unknown …

RNA modifications in cardiovascular diseases, the potential therapeutic targets

Y Wu, S Zhan, Y Xu, X Gao - Life Sciences, 2021 - Elsevier
More than one hundred RNA modifications decorate the chemical and topological properties
of these ribose nucleotides, thereby executing their biological functions through post …

[HTML][HTML] Ythdf2 promotes pulmonary hypertension by suppressing Hmox1-dependent anti-inflammatory and antioxidant function in alveolar macrophages

L Hu, Y Yu, Y Shen, H Huang, D Lin, K Wang, Y Yu… - Redox Biology, 2023 - Elsevier
Pulmonary hypertension (PH) is a devastating disease characterized by irreversible
pulmonary vascular remodeling (PVR) that causes right ventricular failure and death. The …

m6A-TSHub: Unveiling the Context-Specific m6A Methylation and m6A-Affecting Mutations in 23 Human Tissues

B Song, D Huang, Y Zhang, Z Wei, J Su… - Genomics …, 2023 - academic.oup.com
As the most pervasive epigenetic marker present on mRNAs and long non-coding RNAs
(lncRNAs), N 6-methyladenosine (m6A) RNA methylation has been shown to participate in …

Deep learning modeling m6A deposition reveals the importance of downstream cis-element sequences

Z Luo, J Zhang, J Fei, S Ke - Nature communications, 2022 - nature.com
Abstract The N 6-methyladenosine (m6A) modification is deposited to nascent transcripts on
chromatin, but its site-specificity mechanism is mostly unknown. Here we model the m6A …

[HTML][HTML] Inhibition of IGF2BP1 attenuates renal injury and inflammation by alleviating m6A modifications and E2F1/MIF pathway

Y Mao, F Jiang, XJ Xu, LB Zhou, R Jin… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Septic acute kidney injury (AKI) is characterized by inflammation. Pyroptosis often occurs
during AKI and is associated with the development of septic AKI. This study found that …