Interactions of circRNAs with methylation: An important aspect of circRNA biogenesis and function

C Zhang, H Cui, C Huang, F Kong… - Molecular …, 2022 - spandidos-publications.com
Circular RNA (circRNA) molecules are noncoding RNAs with unique circular covalently
closed structures that contribute to gene expression regulation, protein translation and act as …

Relationships of N6-methyladenosine-related long non-coding RNAs with tumor immune microenvironment and clinical prognosis in lung adenocarcinoma

J Zhao, X Lin, J Zhuang, F He - Frontiers in Genetics, 2021 - frontiersin.org
Background: Lung adenocarcinoma (LUAD) is the major subtype of lung cancer and is
associated with very high mortality. Emerging studies have shown that N6-methyladenosine …

Combined signature of N7-methylguanosine regulators with their related genes and the tumor microenvironment: a prognostic and therapeutic biomarker for breast …

T Li, Z Chen, Z Wang, J Lu, D Chen - Frontiers in Immunology, 2023 - frontiersin.org
Background Identifying predictive markers for breast cancer (BC) prognosis and
immunotherapeutic responses remains challenging. Recent findings indicate that N7 …

Epigenetic drugs as new emerging therapeutics: What is the scale's orientation of application and challenges?

MR Farani, M Sarlak, A Gholami, M Azaraian… - … -Research and Practice, 2023 - Elsevier
Epigenetics is the study of heritable changes in gene expression or function without altering
the DNA sequence. Important factors are part of epigenetic events, such as methylation …

Predicting N6-methyladenosine sites in multiple tissues of mammals through ensemble deep learning

Z Luo, L Lou, W Qiu, Z Xu, X Xiao - International Journal of Molecular …, 2022 - mdpi.com
N6-methyladenosine (m6A) is the most abundant within eukaryotic messenger RNA
modification, which plays an essential regulatory role in the control of cellular functions and …

A brief review of machine learning methods for RNA methylation sites prediction

H Wang, S Wang, Y Zhang, S Bi, X Zhu - Methods, 2022 - Elsevier
Thanks to the tremendous advancement of deep sequencing and large-scale profiling,
epitranscriptomics has become a rapidly growing field. As one of the most important parts of …

[HTML][HTML] Crosstalk between m6A and coding/non-coding RNA in cancer and detection methods of m6A modification residues

Q Meng, H Schatten, Q Zhou, J Chen - Aging (Albany NY), 2023 - ncbi.nlm.nih.gov
Abstract N6-methyladenosine (m6A) is one of the most common and well-known internal
RNA modifications that occur on mRNAs or ncRNAs. It affects various aspects of RNA …

METTL3 inhibits autoreactive Th17 cell responses in experimental autoimmune uveitis via stabilizing ASH1L mRNA

L Zhao, Y Liu, B Ma, X Liu, R Wei, H Nian - The FASEB Journal, 2023 - Wiley Online Library
Abstract Methyltransferase like 3 (METTL3), a primary N6‐methyladenosine (m6A)
methyltransferase, has been implicated in various biological and pathological processes …

Current advances in N6-methyladenosine methylation modification during bladder cancer

Q Liu - Frontiers in genetics, 2022 - frontiersin.org
N6-methyladenosine (m6A) is a dynamic, reversible post-transcriptional modification, and
the most common internal modification of eukaryotic messenger RNA (mRNA) …

[HTML][HTML] Occurrence of RNA post-transcriptional modifications in plant viruses and viroids and their correlation with structural and functional features

J Marquez-Molins, VT Juarez-Gonzalez, G Gomez… - Virus Research, 2023 - Elsevier
Post-transcriptional modifications of RNA bases are widespread across all the tree of life
and have been linked to RNA maturation, stability, and molecular interactions. RNA …