Therapeutic mRNAs are generated using modified nucleotides, namely N 1-
methylpseudouridine (m 1 Ψ) triphosphate, so that the mRNA evades detection by the …

Abstract Background N6-methyladenosine (m6A) is the most prevalent post-transcriptional
modification in eukaryotic cells that plays a crucial role in regulating various biological …

Cigarette smoking was known to accelerate the occurrence and development of bladder
cancer by regulating RNA modification. However, the association between the combination …

Background Uncovering functional genetic variants from an allele-specific perspective is of
paramount importance in advancing our understanding of gene regulation and genetic …

Background: Emerging evidence points to the exceptional importance and value of m 7 G
alteration in the diagnosis and prognosis of cancers. Nonetheless, a biomarker for precise …

Chromatin instability plays a crucial role in multiple myeloma (MM) relapse and progression,
but its mechanism remains obscure. Here, we uncovered that m6A-demethylase ALKBH5 …

Summary Although N6-methyladenosine (m6A) modification has been implicated in the
pathogenesis of abdominal aortic aneurysm (AAA), the relationship between m6A …

Ribonucleic acid (RNA) methylation is the most abundant modification in biological systems,
accounting for 60% of all RNA modifications, and affects multiple aspects of RNA (including …

The interaction between hypoxia and RNA N6-methyladenosine (m6A) is an emerging focus
of investigation. However, alterations in m6A modifications at distinct hypoxia levels remain …

Novel insights on regulation of gene expression mechanisms highlight the pivotal role of
epitranscriptomic modifications on decision about transcript fate. These modifications …