ggClusterNet: An R package for microbiome network analysis and modularity‐based multiple network layouts

T Wen, P Xie, S Yang, G Niu, X Liu, Z Ding, C Xue… - Imeta, 2022 - Wiley Online Library
The network analysis has attracted increasing attention and interest from ecological
academics, thus it is of great necessity to develop more convenient and powerful tools. For …

SARS-CoV-2 infection produces chronic pulmonary epithelial and immune cell dysfunction with fibrosis in mice

KH Dinnon III, SR Leist, K Okuda, H Dang… - Science translational …, 2022 - science.org
A subset of individuals who recover from coronavirus disease 2019 (COVID-19) develop
post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV …

Immuno-proteomic profiling reveals aberrant immune cell regulation in the airways of individuals with ongoing post-COVID-19 respiratory disease

B Vijayakumar, K Boustani, PP Ogger, A Papadaki… - Immunity, 2022 - cell.com
Some patients hospitalized with acute COVID-19 suffer respiratory symptoms that persist for
many months. We delineated the immune-proteomic landscape in the airways and …

[HTML][HTML] Prevention of tuberculosis in macaques after intravenous BCG immunization

PA Darrah, JJ Zeppa, P Maiello, JA Hackney… - Nature, 2020 - nature.com
Mycobacterium tuberculosis (Mtb) is the leading cause of death from infection worldwide.
The only available vaccine, BCG (Bacillus Calmette–Guérin), is given intradermally and has …

[HTML][HTML] Platelets contribute to disease severity in COVID‐19

TJ Barrett, S Bilaloglu, M Cornwell, HM Burgess… - Journal of Thrombosis …, 2021 - Elsevier
Objective Heightened inflammation, dysregulated immunity, and thrombotic events are
characteristic of hospitalized COVID‐19 patients. Given that platelets are key regulators of …

Cell stress in cortical organoids impairs molecular subtype specification

A Bhaduri, MG Andrews, W Mancia Leon, D Jung… - Nature, 2020 - nature.com
Cortical organoids are self-organizing three-dimensional cultures that model features of the
developing human cerebral cortex,. However, the fidelity of organoid models remains …

Identification of early neurodegenerative pathways in progressive multiple sclerosis

M Kaufmann, AL Schaupp, R Sun, F Coscia… - Nature …, 2022 - nature.com
Progressive multiple sclerosis (MS) is characterized by unrelenting neurodegeneration,
which causes cumulative disability and is refractory to current treatments. Drug development …

Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer's disease pathogenesis

AP Wingo, Y Liu, ES Gerasimov, J Gockley… - Nature …, 2021 - nature.com
Genome-wide association studies (GWAS) have identified many risk loci for Alzheimer's
disease (AD),, but how these loci confer AD risk is unclear. Here, we aimed to identify loci …

Single-cell RNA-seq technologies and related computational data analysis

G Chen, B Ning, T Shi - Frontiers in genetics, 2019 - frontiersin.org
Single-cell RNA sequencing (scRNA-seq) technologies allow the dissection of gene
expression at single-cell resolution, which greatly revolutionizes transcriptomic studies. A …

[HTML][HTML] DNA methylation GrimAge strongly predicts lifespan and healthspan

AT Lu, A Quach, JG Wilson, AP Reiner, A Aviv… - Aging (albany …, 2019 - ncbi.nlm.nih.gov
It was unknown whether plasma protein levels can be estimated based on DNA methylation
(DNAm) levels, and if so, how the resulting surrogates can be consolidated into a powerful …