Phosphatidylserine orchestrates Myomerger membrane insertions to drive myoblast fusion

DG Gamage, K Melikov… - Proceedings of the …, 2022 - National Acad Sciences
Muscle cell fusion is a multistep process where the final step of the reaction drives
progression beyond early hemifusion events to complete fusion. This step requires activity of …

Fn14 promotes myoblast fusion during regenerative myogenesis

MT da Silva, AS Joshi, MB Castillo… - Life Science …, 2023 - life-science-alliance.org
Skeletal muscle regeneration involves coordinated activation of an array of signaling
pathways. Fibroblast growth factor–inducible 14 (Fn14) is a bona fide receptor for the …

Molecular regulation of myocyte fusion.

TJ Wherley, S Thomas, DP Millay… - Current Topics in …, 2024 - europepmc.org
Myocyte fusion is a pivotal process in the development and regeneration of skeletal muscle.
Failure during fusion can lead to a range of developmental as well as pathological …

[HTML][HTML] Folic acid promotes myoblast migration through Folr1 interacting with RhoA and improves skeletal muscle regeneration

S Li, X Wen, H Teng, Y Yan, H Tong, B Liu, S Li… - Journal of Functional …, 2024 - Elsevier
Folic acid (FA) plays multiple roles in many biological processes. Myoblast intakes FA
through endocytosis by folate receptor 1 (Folr1), which has vital role in regulating muscle …

Profiling of adenine‐derived signaling molecules, cytokinins, in myotubes reveals fluctuations in response to lipopolysaccharide‐induced cell stress

SW Tobin, D Seneviratne, L Phan… - Physiological …, 2023 - Wiley Online Library
Cytokinins (CTKs) are a diverse collection of evolutionarily conserved adenine‐derived
signaling molecules classically studied as phytohormones; however, their roles and …

[HTML][HTML] Zfp697 is an RNA-binding protein that regulates skeletal muscle inflammation and regeneration

JC Correia, PR Jannig, ML Gosztyla, I Cervenka… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Muscular atrophy is a mortality risk factor that happens with disuse, chronic disease, and
aging. Recovery from atrophy requires changes in several cell types including muscle fibers …

Single-nucleus transcriptomic analysis reveals the regulatory circuitry of myofiber XBP1 during regenerative myogenesis

AS Joshi, MB Castillo, M Tomaz da Silva… - bioRxiv, 2024 - biorxiv.org
Endoplasmic reticulum (ER) stress-induced unfolded protein response (UPR) are activated
in skeletal muscle in multiple conditions. However, the role of the UPR in the regulation …

The IRE1α/XBP1 signaling axis drives myoblast fusion in adult skeletal muscle

AS Joshi, MT Da Silva, A Roy, TE Koike, M Wu… - bioRxiv, 2023 - biorxiv.org
Skeletal muscle regeneration involves a signaling network that regulates the proliferation,
differentiation, and fusion of muscle precursor cells to injured myofibers. Inositol requiring …

Long non-coding RNAs and their role in muscle regeneration.

B Biferali, E Mocciaro, V Runfola… - Current Topics in …, 2024 - europepmc.org
In mammals, most of the genome is transcribed to generate a large and heterogeneous
variety of non-protein coding RNAs, that are broadly grouped according to their size. Long …

[PDF][PDF] The IRE1α/XBP1/Myomaker axis drives myoblast fusion in adult skeletal muscle

AS Joshi, MT Da Silva, A Roy, TE Koike, M Wu… - 2023 - researchgate.net
Skeletal muscle regeneration involves a signaling network that regulates the proliferation,
differentiation, and fusion of muscle precursor cells to injured myofibers. Inositol requiring …