[HTML][HTML] Redox signaling in acute pancreatitis

S Pérez, J Pereda, L Sabater, J Sastre - Redox biology, 2015 - Elsevier
Acute pancreatitis is an inflammatory process of the pancreatic gland that eventually may
lead to a severe systemic inflammatory response. A key event in pancreatic damage is the …

Going up in flames: necrotic cell injury and inflammatory diseases

S Challa, FKM Chan - Cellular and molecular life sciences, 2010 - Springer
Recent evidence indicates that cell death can be induced through multiple mechanisms.
Strikingly, the same death signal can often induce apoptotic as well as non-apoptotic cell …

Naturally Produced Outer Membrane Vesicles from Pseudomonas aeruginosa Elicit a Potent Innate Immune Response via Combined Sensing of Both …

TN Ellis, SA Leiman, MJ Kuehn - Infection and immunity, 2010 - Am Soc Microbiol
Pseudomonas aeruginosa is a prevalent opportunistic human pathogen that, like other
Gram-negative pathogens, secretes outer membrane vesicles. Vesicles are complex entities …

Histone acetyltransferase PCAF regulates inflammatory molecules in the development of renal injury

J Huang, D Wan, J Li, H Chen, K Huang, L Zheng - Epigenetics, 2015 - Taylor & Francis
Kidney diseases, including chronic kidney disease (CKD) and acute kidney injury (AKI), are
associated with inflammation. The mechanism that regulates inflammation in these renal …

The common chymotrypsinogen C (CTRC) variant G60G (C. 180T) increases risk of chronic pancreatitis but not recurrent acute pancreatitis in a North American …

J LaRusch, A Lozano-Leon, K Stello… - Clinical and …, 2015 - journals.lww.com
OBJECTIVES: Recurrent acute pancreatitis (RAP) is a complex inflammatory disorder that
may progress to fibrosis and other irreversible features recognized as chronic pancreatitis …

Superoxide dismutase mimetic nanoceria restrains cerulein induced acute pancreatitis

A Khurana, P Anchi, P Allawadhi, V Kumar… - …, 2019 - Taylor & Francis
Aim: The present study was carried out to assess the effect of nanoceria (NC) on pancreatic
inflammation caused by cerulein. Methods: NC was characterized and in vitro studies were …

Yttrium oxide nanoparticles reduce the severity of acute pancreatitis caused by cerulein hyperstimulation

A Khurana, P Anchi, P Allawadhi, V Kumar… - … , Biology and Medicine, 2019 - Elsevier
Oxidative stress plays a major role in acute pancreatitis (AP), leading to massive
macrophage infiltration. Nanoyttria (NY) possesses potent free radical scavenging activity …

Redox signaling and histone acetylation in acute pancreatitis

J Escobar, J Pereda, G López-Rodas… - Free Radical Biology and …, 2012 - Elsevier
Histone acetylation via CBP/p300 coordinates the expression of proinflammatory cytokines
in the activation phase of inflammation, particularly through mitogen-activated protein …

Pharmacological blockade of PCAF ameliorates osteoarthritis development via dual inhibition of TNF-α-driven inflammation and ER stress

D Chen, D Lu, H Liu, E Xue, Y Zhang, P Shang… - …, 2019 - thelancet.com
Background Epigenetic mechanisms have been reported to play key roles in osteoarthritis
(OA) development. P300/CBP-associated factor (PCAF) is a member of the histone …

Effects of down-regulation of microRNA-23a on TNF-α-induced endothelial cell apoptosis through caspase-dependent pathways

W Ruan, J Xu, S Li, L Yuan, R Dai - Cardiovascular research, 2012 - academic.oup.com
Aims Endothelial cell injury induced by inflammatory factors plays a critical role in the
pathogenesis of numerous vascular diseases. MicroRNAs are well known to be implicated …