Arginase, a binuclear manganese metalloenzyme in the urea, catalyzes the hydrolysis of L-
arginine to urea and L-ornithine. Both isoforms, arginase 1 and arginase 2 perform …

The primary role of red blood cells (RBCs) is to transport oxygen to the tissues and carbon
dioxide to the lungs. However, emerging evidence suggests an important role of the RBC …

Nitric oxide (NO) is one of the most important molecules released by endothelial cells, and
its antiatherogenic properties support cardiovascular homeostasis. Diminished NO …

We recently showed that red blood cells (RBCs) from patients with type 2 diabetes mellitus
(T2DM-RBCs) induce endothelial dysfunction through a mechanism involving arginase I and …

Endothelial dysfunction represents an early change in the vascular wall in areas prone to
atherosclerotic plaque formation and is present in association with several risk factors for …

Background: Erythrocytes (red blood cells) participate in the control of vascular NO
bioavailability. The purpose of this study was to determine whether and how genetic deletion …

Amyl nitrite was introduced in 1867 as the first molecule of a new class of agents for the
treatment of angina pectoris. In the following 150 years, the nitric oxide pathway has been …

Endothelial dysfunction, associated with depressed nitric oxide (NO) bioavailability, is a well-
recognized contributor to both accelerated atherogenesis and microvascular complications …

Whole blood viscosity (WBV) is the intrinsic resistance to flow developed due to the frictional
force between adjacent layers of flowing blood. Elevated WBV is an independent risk factor …

Simple Summary Multiple myeloma is a plasma cell disorder that accounts for around 10%
of all haematological malignancies. This neoplasia is often associated with a significant …