Human-based evidence for the therapeutic potential of arginase inhibitors in cardiovascular diseases

J Moretto, M Pudlo, C Demougeot - Drug Discovery Today, 2021 - Elsevier
Cardiovascular diseases (CVDs) are some of the leading causes of mortality and morbidity
worldwide. They include conditions such as hypertension, coronary artery disease (CAD) …

The role of arginase in the microcirculation in cardiovascular disease

B Wernly, J Pernow, M Kelm… - Clinical Hemorheology …, 2020 - content.iospress.com
In the microcirculation, the exchange of nutrients, water, gas, hormones, and waste takes
place, and it is divided into the three main sections arterioles, capillaries, and venules …

The role of the complement factor B‒arginase‒polyamine molecular axis in uremia‐induced cardiac remodeling in mice

Y Yang, L Ma, M Song, X Li, F He… - European Journal of …, 2020 - Wiley Online Library
The role of complement system in heart diseases is controversial. Besides, the mechanisms
by which complement components participate in cardiac remodeling (CR) and heart failure …

Removal of nitrate and nitrite by hemodialysis in end-stage renal disease and by sustained low-efficiency dialysis in acute kidney injury

AH Martinez, GR Diez, V Ferraris, PA Coccia… - Nitric Oxide, 2020 - Elsevier
Background & purpose It is well established that end-stage renal disease (ESRD) is
associated with increased cardiovascular morbidity and mortality both in the adult and …

An Update on Arginase Inhibitors and Inhibitory Assays

J Muller, R Attia, A Zedet, C Girard… - Mini Reviews in …, 2022 - ingentaconnect.com
Arginase, which converts arginine into ornithine and urea, is a promising therapeutic target.
Arginase is involved in cardiovascular diseases, parasitic infections and through a critical …

[PDF][PDF] Erythrocytes and cardiovascular complications

Z Zhou, J Yang, J Pernow - Aging (Albany NY), 2018 - pdfs.semanticscholar.org
Zhichao Zhou, Jiangning Yang, John Pernow www. aging-us. com AGING 2018, Vol. 10, No.
12 www. aging-us. com 3643 AGING observed in the aorta from type 2 diabetic rats. This …

Circular RNA HMGCS1 sponges miR-4521 to aggravate type 2 diabetes-induced vascular endothelial dysfunction

M Zhang, G Du, L Xie, Y Xu, W Chen - bioRxiv, 2024 - biorxiv.org
Noncoding RNA plays a pivotal role as novel regulators of endothelial cell function. Type 2
diabetes, acknowledged as a primary contributor to cardiovascular diseases, plays a vital …

[PDF][PDF] 丹红注射液辅助西药对脑血栓患者氧化应激及血管内皮功能的影响

牛静, 孙金, 张迪, 周伦, 史明, 任茜… - Progress in Modern …, 2021 - biomed.cnjournals.com
摘要目的: 研究丹红注射液辅助西药对脑血栓患者氧化应激及血管内皮功能的影响. 方法:
选择2018 年1 月~ 2019 年12 月于我院诊治的90 例脑血栓患者, 根据治疗方法将其分为两组 …

雌激素对肾缺血再灌注损伤大鼠Th17/Treg 平衡, 氧化应激及肾组织NF-κB, TGF-β1 表达的影响.

孟巧云, 王雪, 邱国萍, 张苗… - Progress in Modern …, 2021 - search.ebscohost.com
To study the effects of estrogen on Th17/Treg balance, oxidative stress and the expression
of NF-资B and TGF-茁1 in renal tissue of rats with renal ischemia-reperfusion injury (RIRI) …

[HTML][HTML] Effect of 8 Weeks of Aerobic Exercise With Cinnamon Extract Supplementation on Arginase and p38 MAPK Levels of Soleus Muscle in Diabetic Rats

V Valipour Dehnou, E Ghahramanlou… - Complementary …, 2022 - cmja.arakmu.ac.ir
Methods In this study, 35 male Wistar rats aged 8 weeks, after 7 days of adaptation to the
new environment, induction of diabetes and adaptation to exercise on a treadmill, were …