[HTML][HTML] The use of in vivo confocal microscopy in fungal keratitis–Progress and challenges

IM Bakken, CJ Jackson, TP Utheim, E Villani… - The ocular …, 2022 - Elsevier
Fungal keratitis (FK) is a serious and sight-threatening corneal infection with global reach.
The need for prompt diagnosis is paramount, as a delay in initiation of treatment could lead …

Immunity to pathogenic fungi in the eye

S Abbondante, SM Leal, HL Clark, B Ratitong… - Seminars in …, 2023 - Elsevier
Abstract Fusarium, Aspergillus and Candida are important fungal pathogens that cause
visual impairment and blindness in the USA and worldwide. This review will summarize the …

[HTML][HTML] The case for fungal keratitis to be accepted as a neglected tropical disease

L Brown, G Kamwiziku, RO Oladele, MJ Burton… - Journal of Fungi, 2022 - mdpi.com
Amongst the treatable cause of blindness among young people, fungal keratitis ranks high.
There are an estimated 1,051,787 to 1,480,916 eyes affected annually, with 8–11% of …

[HTML][HTML] Itraconazole loaded nano-structured lipid carrier for topical ocular delivery: Optimization and evaluation

M Kumar, A Tiwari, SMB Asdaq, AB Nair, S Bhatt… - Saudi Journal of …, 2022 - Elsevier
Abstract Background & Objectives Low penetration efficiency and retention time are the
main therapeutic concerns that make it difficult for most of the drugs to be delivered to the …

[HTML][HTML] Fusarium Keratitis—Review of Current Treatment Possibilities

M Szaliński, A Zgryźniak, I Rubisz, M Gajdzis… - Journal of Clinical …, 2021 - mdpi.com
In many parts of the world, fungi are the predominant cause of infectious keratitis; among
which, Fusarium is the most commonly isolated pathogen. The clinical management of this …

[HTML][HTML] Preparation and evaluation of modified chitosan nanoparticles using anionic sodium alginate polymer for treatment of ocular disease

VA Bhosale, V Srivastava, B Valamla, R Yadav… - Pharmaceutics, 2022 - mdpi.com
Mucoadhesive nanoparticles offer prolonged drug residence time at the corneal epithelium
by adhering to the mucous layer of the eye. Here, in this research investigation, voriconazole …

[HTML][HTML] Topical chlorhexidine 0.2% versus topical natamycin 5% for the treatment of fungal keratitis in nepal: a randomized controlled noninferiority trial

JJ Hoffman, R Yadav, SD Sanyam, P Chaudhary… - Ophthalmology, 2022 - Elsevier
Purpose To investigate if topical chlorhexidine 0.2%, which is low cost and easy to
formulate, is noninferior to topical natamycin 5% for the treatment of filamentous fungal …

Caspase-8 is involved in pyroptosis, necroptosis and the maturation and release of IL-1β in Aspergillus fumigatus keratitis

L Wang, H Yan, X Chen, J Lee, J Sun, G Liu… - International …, 2022 - Elsevier
Purpose To explore the role of caspase-8 in mediating the transition between different death
modes in fungal keratitis. Methods The expression of caspase-8 in Aspergillus fumigatus (A …

[HTML][HTML] Eye infections caused by filamentous fungi: spectrum and antifungal susceptibility of the prevailing agents in Germany

G Walther, A Zimmermann, J Theuersbacher… - Journal of fungi, 2021 - mdpi.com
Fungal eye infections can lead to loss of vision and blindness. The disease is most prevalent
in the tropics, although case numbers in moderate climates are increasing as well. This …

[HTML][HTML] Microbial keratitis in Nepal: predicting the microbial aetiology from clinical features

JJ Hoffman, R Yadav, SD Sanyam, P Chaudhary… - Journal of Fungi, 2022 - mdpi.com
Fungal corneal infection (keratitis) is a common clinical problem in South Asia. However, it is
often challenging to distinguish this from other aetiologies, such as bacteria or …