CLC anion transporters are found in all phyla and form a gene family of eight members in
mammals. Two CLC proteins, each of which completely contains an ion translocation …

The bone is an essential organ for locomotion and protection of the body, as well as
hematopoiesis and mineral homeostasis. In order to exert these functions throughout life …

During the past three decades, mice, zebrafish, fruit flies, and Caenorhabditis elegans have
been the primary model organisms used for the study of various biological phenomena …

Osteopetrosis is a genetic condition of increased bone mass, which is caused by defects in
osteoclast formation and function. Both autosomal recessive and autosomal dominant forms …

OBJECTIVES: To review the current literature on the regulation of bone remodelling at the
cellular level. DESIGN AND METHODS: The cellular activities of the cells in the basic …

Osteoporosis, a disease endemic in Western society, typically reflects an imbalance in
skeletal turnover so that bone resorption exceeds bone formation. Bone resorption is the …

The adult skeleton regenerates by temporary cellular structures that comprise teams of
juxtaposed osteoclasts and osteoblasts and replace periodically old bone with new. A …

Osteoclasts are the principal, if not exclusive, bone-resorbing cells, and their activity has a
profound impact on skeletal health. So, disorders of skeletal insufficiency, such as …

Zinc is required for the activity of> 300 enzymes, covering all six classes of enzymes. Zinc
binding sites in proteins are often distorted tetrahedral or trigonal bipyramidal geometry …

Osteoclasts are multinucleated cells of monocyte/macrophage origin that degrade bone
matrix. The differentiation of osteoclasts is dependent on a tumor necrosis factor (TNF) family …