[HTML][HTML] Understanding bacteriophage tail fiber interaction with host surface receptor: the key “blueprint” for reprogramming phage host range

J Taslem Mourosi, A Awe, W Guo, H Batra… - International Journal of …, 2022 - mdpi.com
Bacteriophages (phages), as natural antibacterial agents, are being rediscovered because
of the growing threat of multi-and pan-drug-resistant bacterial pathogens globally. However …

Unlocking the next generation of phage therapy: the key is in the receptors

FLG Altamirano, JJ Barr - Current Opinion in Biotechnology, 2021 - Elsevier
Highlights•Phages need to attach to a receptor on the bacterial surface to initiate infection.•It
is not common practice to identify these receptors before phage therapy use.•Identifying …

[HTML][HTML] Reprogramming bacteriophage host range through structure-guided design of chimeric receptor binding proteins

M Dunne, B Rupf, M Tala, X Qabrati, P Ernst, Y Shen… - Cell reports, 2019 - cell.com
Bacteriophages provide excellent tools for diagnostics, remediation, and targeted
microbiome manipulation, yet isolating viruses with suitable host specificity remains …

Fitness trade-offs resulting from bacteriophage resistance potentiate synergistic antibacterial strategies

MR Mangalea, BA Duerkop - Infection and immunity, 2020 - Am Soc Microbiol
Bacteria that cause life-threatening infections in humans are becoming increasingly difficult
to treat. In some instances, this is due to intrinsic and acquired antibiotic resistance …

[HTML][HTML] Engineered bacteriophage therapeutics: rationale, challenges and future

M Łobocka, K Dąbrowska, A Górski - BioDrugs, 2021 - Springer
The current problems with increasing bacterial resistance to antibacterial therapies, resulting
in a growing frequency of incurable bacterial infections, necessitates the acceleration of …

Bacteriophage-based advanced bacterial detection: Concept, mechanisms, and applications

W Hussain, MW Ullah, U Farooq, A Aziz… - Biosensors and …, 2021 - Elsevier
Some bacterial species are deadly disease-causing pathogens with high morbidity and
mortality in humans worldwide. Key interfaces in the transmission of bacterial pathogens …

[HTML][HTML] L-form conversion in Gram-positive bacteria enables escape from phage infection

JC Wohlfarth, M Feldmüller, A Schneller, S Kilcher… - Nature …, 2023 - nature.com
At the end of a lytic bacteriophage replication cycle in Gram-positive bacteria, peptidoglycan-
degrading endolysins that cause explosive cell lysis of the host can also attack non-infected …

[HTML][HTML] Reprogramming bacteriophage host range: design principles and strategies for engineering receptor binding proteins

M Dunne, NS Prokhorov, MJ Loessner… - Current opinion in …, 2021 - Elsevier
Highlights•Phages use structurally diverse receptor binding proteins (RBPs) to target
different cell wall structures.•RBPs play a critical role in spatial and temporal positioning of …

Biological foundations of successful bacteriophage therapy

C Venturini, A Petrovic Fabijan… - EMBO Molecular …, 2022 - embopress.org
Bacteriophages (phages) are selective viral predators of bacteria. Abundant and ubiquitous
in nature, phages can be used to treat bacterial infections (phage therapy), including …

[HTML][HTML] Bacteriophage-based biosensors: A platform for detection of foodborne bacterial pathogens from food and environment

RR Al-Hindi, AD Teklemariam, MG Alharbi, I Alotibi… - Biosensors, 2022 - mdpi.com
Foodborne microorganisms are an important cause of human illness worldwide. Two-thirds
of human foodborne diseases are caused by bacterial pathogens throughout the globe …