This comprehensive review explores vimentin as a pivotal therapeutic target in cancer
treatment, with a primary focus on mitigating metastasis and overcoming drug resistance …

Colorectal cancer (CRC) is traditionally considered to be a genetically driven disease.
However, nongenetic plasticity has recently emerged as a major driver of tumour initiation …

The cell membrane is a crucial component of cells, protecting their integrity and stability
while facilitating signal transduction and information exchange. Therefore, disrupting its …

Peptide‐based supramolecular therapeutics (PST) refer to those theranostic nanomedicines
based on peptide or peptide derivatives self‐assembly that are constructed in vitro or in vivo …

The SLC3A2 gene encodes for a cell-surface transmembrane protein CD98hc (4F2).
CD98hc serves as a chaperone for LAT1 (SLC7A5), LAT2 (SLC7A8), y+ LAT1 (SLC7A7), y+ …

Metformin and IACS‐010759 are two distinct antimetabolic agents. Metformin, an
established antidiabetic drug, mildly inhibits mitochondrial complex I, while IACS‐010759 is …

Cancer is a complex disease displaying a variety of cell states and phenotypes. This
diversity, known as cancer cell plasticity, confers cancer cells the ability to change in …

Ferroptotic cancer therapy has been extensively investigated since the genesis of the
ferroptosis concept. However, the therapeutic efficacy of ferroptosis induction in …

The development of cancer begins with cells transitioning from their multicellular nature to a
state akin to unicellular organisms. This shift leads to a breakdown in the crucial regulators …

Cancer's complexity is in part due to the presence of intratumor heterogeneity and the
dynamic nature of cancer cell plasticity, which create substantial obstacles in effective …