Pathological role of angiotensin II in severe COVID-19

W Miesbach - TH open, 2020 - thieme-connect.com
The activated renin–angiotensin system induces a prothrombotic state resulting from the
imbalance between coagulation and fibrinolysis. Angiotensin II is the central effector …

Nitric oxide-enhancing or-releasing agents as antithrombotic drugs

P Gresele, S Momi, G Guglielmini - Biochemical Pharmacology, 2019 - Elsevier
Nitric oxide (NO) is a powerful biological mediator provided with a number of activities of
relevance for the prevention of thrombosis, like vasodilation, inhibition of platelet adhesion …

Angiotensin II–mediated microvascular thrombosis

EY Senchenkova, J Russell, LD Almeida-Paula… - …, 2010 - Am Heart Assoc
Hypertension is associated with an increased risk of thrombosis that appears to involve an
interaction between the renin-angiotensin system and hemostasis. In this study we …

Layered double hydroxides as supports for intercalation and sustained release of antihypertensive drugs

SJ Xia, ZM Ni, Q Xu, BX Hu, J Hu - Journal of Solid State Chemistry, 2008 - Elsevier
Zn/Al layered double hydroxides (LDHs) were intercalated with the anionic antihypertensive
drugs Enalpril, Lisinopril, Captopril and Ramipril by using coprecipitation or ion-exchange …

Development of drug delivery systems based on layered hydroxides for nanomedicine

F Barahuie, MZ Hussein, S Fakurazi… - International journal of …, 2014 - mdpi.com
Layered hydroxides (LHs) have recently fascinated researchers due to their wide application
in various fields. These inorganic nanoparticles, with excellent features as nanocarriers in …

Centrally acting angiotensin-converting enzyme inhibitor suppresses type I interferon responses and decreases inflammation in the periphery and the CNS in lupus …

C Nocito, C Lubinsky, M Hand, S Khan, T Patel… - Frontiers in …, 2020 - frontiersin.org
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multi-
organ damage. Neuropsychiatric lupus (NPSLE) is one of the most common manifestations …

Kiwifruit decreases blood pressure and whole-blood platelet aggregation in male smokers

A Karlsen, M Svendsen, I Seljeflot, P Laake… - Journal of human …, 2013 - nature.com
Lifestyle modifications to reduce risk factors for cardiovascular diseases such as blood
pressure (BP) and smoking have been emphasized. Fruits and vegetables may modify such …

Strategies for antiplatelet targets and agents

YZ Xiang, LY Kang, XM Gao, HC Shang, JH Zhang… - Thrombosis research, 2008 - Elsevier
Platelets play a key role in thrombosis and haemostasis, which can be either beneficial or
deleterious depending on the circumstance. Antiplatelet therapy is the 'cornerstone'in the …

Anticoagulant Activity of Low-Molecular Weight Compounds from Heterometrus laoticus Scorpion Venom

TV Tran, AN Hoang, TTT Nguyen, TV Phung… - Toxins, 2017 - mdpi.com
Scorpion venoms are complex polypeptide mixtures, the ion channel blockers and
antimicrobial peptides being the best studied components. The coagulopathic properties of …

[PDF][PDF] Contribution of captopril thiol group to the prevention of spontaneous hypertension

O Pecháňová - Physiol Res, 2007 - biomed.cas.cz
We aimed to compare the effect of angiotensin converting enzyme (ACE) inhibitors captopril
(containing thiol group) and enalapril (without thiol group) on the development of …