Increasingly, primary hypertension is being considered a syndrome and not a disease, with
the individual causes (diseases) having a common sign—an elevated blood pressure. To …

The incidence of hypertension with diabetes mellitus (DM) as a co-morbid condition is on the
rise worldwide. In 2000, an estimated 972 million adults had hypertension, which is …

Hypertension is the most prevalent cause of cardiovascular disease and kidney failure, but
only about 50% of patients achieve adequate blood pressure control, in part, due to inter …

After the recent description of the human genome by the ENCODE and the FANTOM
consortia, major attention has been addressed to the so-called “genomic noise”, which …

The rising prevalence of primary pediatric hypertension and its tracking into adult
hypertension point to the importance of determining its pathogenesis to gain insights into its …

Angiotensinogen (AGT) is the precursor of one of the most potent vasoconstrictors, peptide
angiotensin II. Genome-wide association studies have shown that two A/G polymorphisms …

Hypertension is a serious risk factor for cardiovascular disease. Like other complex disease,
hypertension is caused by a combination of genetic and environmental factors. The renin …

Single nucleotide polymorphisms (SNPs) in the human angiotensinogen (hAGT) gene may
modulate its transcription and affect the regulation of blood pressure via activation of the …

The human angiotensinogen (hAGT) gene has polymorphisms in its 2.5-kb promoter that
form two haplotype (Hap) blocks:− 6A/G (− 1670A/G,− 1562C/T, and− 1561T/C) and …

The renin-angiotensin system plays an important role in the regulation of blood pressure via
angiotensin II and the angiotensin II receptor type 1 (AT 1 R). Human AT 1 R gene promoter …