The molecular hybridization approach has been used to develop compounds with improved
efficacy by combining two or more pharmacophores of bioactive scaffolds. In this context …

Low quality of life and life-threatening conditions often demand pharmacological screening
of lead compounds. A spectrum of pharmacological activities has been attributed to pyrazole …

Abstract Background and Objective In clinical practice, injectable drug combination (IDC)
usually provides good therapeutic effects for patients. Numerous clinical studies have …

Two goals motivate treating diseases with drug combinations: reduce off-target toxicity by
minimizing doses (synergistic potency) and improve outcomes by escalating effect …

Simple Summary Nucleic acid drugs provide novel therapeutic modalities with
characteristics that differ from those of small molecules and antibodies. In this review, I focus …

By harnessing artificial intelligence (AI) algorithms and machine learning techniques, the
entire drug discovery process stands to undergo a profound transformation, offering a …

Drug combination is a sensible strategy for disease treatment because it improves the
treatment efficacy and reduces concomitant side effects. Due to the large number of possible …

Triptolide (TP), a major extract of the herb Tripterygium wilfordii Hook F (TWHF), has been
shown to exert potent pharmacological effects, especially an immunosuppressive effect in …

With the rapid development of systems-based pharmacology and poly-pharmacology,
method development for rational design of multi-target drugs has becoming urgent. In this …

Hepatocellular carcinoma (HCC) is the third most frequent cause of tumor-related mortality
and there are an estimated approximately 850,000 new cases annually. Most HCC patients …