The passage of the Best Pharmaceuticals for Children Act and the Pediatric Research Equity
Act has collectively resulted in an improvement in rational prescribing for children, including …

Introduction: New antipsychotics continuously arrive on the market, which thereby influences
the approved and off-label prescribing (OLP) schemes. We aimed to identify the recent …

Objective: This systematic review summarizes the published incidence of off-label
medication use in children from the past 10 years. We also performed a retrospective chart …

BACKGROUND: Off-label drug use in children is common and potentially harmful. In most
previous off-label use research, authors studied hospitalized children, specific drug classes …

Background: Worldwide, in the absence of standard pediatric prescribing information,
clinicians often use medicines in children in a dosage form or for an indication that has not …

Off-label use of drugs is widely known as unapproved use of approved drugs, and it can be
perceived as a relatively simple concept. Even though it has been in existence for many …

Background In the past two decades, many legislative and regulatory initiatives were taken
globally to improve drug use in children. However, children are still found to be prescribed …

Background: Given the growing use of off-label in pediatric practice, there is a growing
interest on pharmacovigilance programs monitoring the occurrence of adverse drug …

Adverse drug reactions (ADRs) represent a major health problem worldwide, with high
morbidity and mortality rates. ADRs are classified into Type A (augmented) and Type B …

Background Drug repurposing (ie, finding novel uses for existing drugs) is essential for
maximizing medicines' therapeutic utility, but obtaining regulatory approval for new …