Current state and future of polygenic risk scores in cardiometabolic disease: a scoping review
A polygenic risk score (PRS) is derived from a genome-wide association study and
represents an aggregate of thousands of single-nucleotide polymorphisms that provide a …
represents an aggregate of thousands of single-nucleotide polymorphisms that provide a …
Challenges in pea breeding for tolerance to drought: Status and prospects
M Bagheri, CS Santos, D Rubiales… - Annals of Applied …, 2023 - Wiley Online Library
Drought is increasingly frequent in the context of climate change and is considered a major
constraint for crop yield. Water scarcity can impair growth, disturb plant water relations and …
constraint for crop yield. Water scarcity can impair growth, disturb plant water relations and …
[HTML][HTML] Effects of CYP2C19 and CYP2D6 gene variants on escitalopram and aripiprazole treatment outcome and serum levels: results from the CAN-BIND 1 study
Cytochrome P450 drug-metabolizing enzymes may contribute to interindividual differences
in antidepressant outcomes. We investigated the effects of CYP2C19 and CYP2D6 gene …
in antidepressant outcomes. We investigated the effects of CYP2C19 and CYP2D6 gene …
A polygenic risk score for predicting racial and genetic susceptibility to prurigo nodularis
Prurigo nodularis (PN) is an understudied inflammatory skin disease characterized by
pruritic, hyperkeratotic nodules. Identifying the genetic factors underlying PN could help to …
pruritic, hyperkeratotic nodules. Identifying the genetic factors underlying PN could help to …
[HTML][HTML] Genetic determinants of Biofilm formation of Helicobacter pylori using whole-genome sequencing
KA Fauzia, H Aftab, M Miftahussurur, LA Waskito… - BMC microbiology, 2023 - Springer
Abstract Background Infection with Helicobacter pylori as the cause of gastric cancer is a
global public health concern. In addition to protecting germs from antibiotics, biofilms reduce …
global public health concern. In addition to protecting germs from antibiotics, biofilms reduce …
Rye: genetic ancestry inference at biobank scale
AB Conley, L Rishishwar, M Ahmad… - Nucleic Acids …, 2023 - academic.oup.com
Biobank projects are generating genomic data for many thousands of individuals.
Computational methods are needed to handle these massive data sets, including genetic …
Computational methods are needed to handle these massive data sets, including genetic …
Influence of CYP2C19, CYP2D6, and ABCB1 Gene Variants and Serum Levels of Escitalopram and Aripiprazole on Treatment-Emergent Sexual Dysfunction: A …
Objectives Treatment-emergent sexual dysfunction is frequently reported by individuals with
major depressive disorder (MDD) on antidepressants, which negatively impacts treatment …
major depressive disorder (MDD) on antidepressants, which negatively impacts treatment …
Limitations of principal components in quantitative genetic association models for human studies
Y Yao, A Ochoa - Elife, 2023 - elifesciences.org
Abstract Principal Component Analysis (PCA) and the Linear Mixed-effects Model (LMM),
sometimes in combination, are the most common genetic association models. Previous PCA …
sometimes in combination, are the most common genetic association models. Previous PCA …
[HTML][HTML] The Inclusion of Underrepresented Populations in Cardiovascular Genetics and Epidemiology
E Chappell, L Arbour, Z Laksman - Journal of Cardiovascular …, 2024 - mdpi.com
Novel genetic risk markers have helped us to advance the field of cardiovascular
epidemiology and refine our current understanding and risk stratification paradigms. The …
epidemiology and refine our current understanding and risk stratification paradigms. The …
[PDF][PDF] Current State and Future of Polygenic Risk Scores in Cardiometabolic Disease: A Scoping
A polygenic risk score (PRS) is derived from a genome-wide association study and
represents an aggregate of thousands of single-nucleotide polymorphisms that provide a …
represents an aggregate of thousands of single-nucleotide polymorphisms that provide a …