[HTML][HTML] Targeting novel regulated cell death: Ferroptosis, pyroptosis, and autophagy in sepsis-associated encephalopathy

J Sun, JS Fleishman, X Liu, H Wang, L Huo - Biomedicine & …, 2024 - Elsevier
Abstract Sepsis-associated encephalopathy (SAE), a common neurological complication of
sepsis, is a heterogenous complex clinical syndrome caused by the dysfunctional response …

Research progress of macromolecules in the prevention and treatment of sepsis

J Su, S Wu, F Zhou, Z Tong - International Journal of Molecular Sciences, 2023 - mdpi.com
Sepsis is associated with high rates of mortality in the intensive care unit and accompanied
by systemic inflammatory reactions, secondary infections, and multiple organ failure …

[HTML][HTML] Synthesis, in silico analysis, and biomedical effects of coumarins derived from resveratrol

YF Mustafa - Phytomedicine plus, 2023 - Elsevier
Background Resveratrol (RVL) is a polyphenol-containing natural product found in a variety
of plants, including peanuts, grapes, and berry fruits. The use of RVL is linked in a great deal …

Enhanced efficacy of resveratrol-loaded silver nanoparticle in attenuating sepsis-induced acute liver injury: Modulation of inflammation, oxidative stress, and sirt1 …

H Üstündağ, FD Kalindemirtaş, S Doğanay, Ö Demir… - Shock, 2023 - journals.lww.com
Sepsis-induced acute liver injury is a life-threatening condition involving inflammation,
oxidative stress, and endothelial dysfunction. In the present study, the preventive effects of …

Causal effects of gut microbiota on sepsis and sepsis-related death: insights from genome-wide Mendelian randomization, single-cell RNA, bulk RNA sequencing …

S Yang, J Guo, Z Kong, M Deng, J Da, X Lin… - Journal of Translational …, 2024 - Springer
Background Gut microbiota alterations have been implicated in sepsis and related infectious
diseases, but the causal relationship and underlying mechanisms remain unclear. Methods …

Prognostic value of soluble endoglin in patients with septic shock and severe COVID-19

V Tomášková, A Mýtniková… - Frontiers in …, 2022 - frontiersin.org
Sepsis is a clinical syndrome characterized by a dysregulated response to infection. It
represents a leading cause of mortality in ICU patients worldwide. Although sepsis is in the …

Molecular mechanisms of oxidative stress in acute kidney injury: Targeting the loci by resveratrol

H Rashid, A Jali, MS Akhter, SAH Abdi - International Journal of …, 2023 - mdpi.com
Reactive oxygen species are a group of cellular molecules that stand as double-edged
swords, their good and bad being discriminated by a precise balance. Several metabolic …

Evaluation of the protective role of resveratrol against sepsis caused by LPS via TLR4/NF‐κB/TNF‐α signaling pathways: Experimental study

A Okan, Z Doğanyiğit, S Yilmaz, S Uçar… - Cell Biochemistry …, 2023 - Wiley Online Library
The development and progression of sepsis are multifactorial and influence the
immunological, endocrine, and cardiovascular systems of the body. Our knowledge of the …

Treatment of septic encephalopathy and encephalitis–a critical appraisal

SC Tauber, R Nau - Expert Review of Neurotherapeutics, 2023 - Taylor & Francis
Introduction The central nervous system is frequently involved during severe sepsis. Patients
either develop septic encephalopathy characterized by delirium and coma or focal …

Dysregulated autophagy-related genes in septic cardiomyopathy: comprehensive bioinformatics analysis based on the human transcriptomes and experimental …

HX Zou, BQ Qiu, ZY Zhang, T Hu, L Wan… - Frontiers in …, 2022 - frontiersin.org
Septic cardiomyopathy (SCM) is severe organ dysfunction caused by sepsis that is
associated with poor prognosis, and its pathobiological mechanisms remain unclear …