Physiological and pharmacological modulation of BAX

AZ Spitz, E Gavathiotis - Trends in pharmacological sciences, 2022 - cell.com
Bcl-2-associated X protein (BAX) is a critical executioner of mitochondrial regulated cell
death through its lethal activity of permeabilizing the mitochondrial outer membrane (MOM) …

Viral infections and systemic lupus erythematosus: new players in an old story

M Quaglia, G Merlotti, M De Andrea, C Borgogna… - Viruses, 2021 - mdpi.com
A causal link between viral infections and autoimmunity has been studied for a long time
and the role of some viruses in the induction or exacerbation of systemic lupus …

Epstein–Barr virus reprograms human B lymphocytes immediately in the prelatent phase of infection

P Mrozek-Gorska, A Buschle, D Pich… - Proceedings of the …, 2019 - National Acad Sciences
Epstein–Barr virus (EBV) is a human tumor virus and a model of herpesviral latency. The
virus efficiently infects resting human B lymphocytes and induces their continuous …

Organization of the skin immune system and compartmentalized immune responses in infectious diseases

JAS Quaresma - Clinical microbiology reviews, 2019 - Am Soc Microbiol
The skin is an organ harboring several types of immune cells that participate in innate and
adaptive immune responses. The immune system of the skin comprises both skin cells and …

Infectious Mononucleosis: diagnosis and clinical interpretation

P Naughton, M Healy, F Enright… - British journal of …, 2021 - Taylor & Francis
ABSTRACT EBV is the sole causative agent of the acute illness in humans described either
as infectious mononucleosis (IM), or glandular fever. IM, when not clinically silent, can …

Epstein–Barr virus-associated malignancies: Roles of viral oncoproteins in carcinogenesis

A El-Sharkawy, L Al Zaidan, A Malki - Frontiers in oncology, 2018 - frontiersin.org
The Epstein–Barr virus (EBV) is the first herpesvirus identified to be associated with human
cancers known to infect the majority of the world population. EBV-associated malignancies …

BHRF1, a BCL2 viral homolog, disturbs mitochondrial dynamics and stimulates mitophagy to dampen type I IFN induction

G Vilmen, D Glon, G Siracusano, M Lussignol, Z Shao… - Autophagy, 2021 - Taylor & Francis
Mitochondria respond to many cellular functions and act as central hubs in innate immunity
against viruses. This response is notably due to their role in the activation of interferon (IFN) …

Oncogenic viruses as entropic drivers of cancer evolution

I Tempera, PM Lieberman - Frontiers in virology, 2021 - frontiersin.org
Viral infection is an indisputable causal factor for nearly 17% of all human cancers.
However, the diversity and complexity of oncogenic mechanisms raises new questions as to …

Highways to hell: Mechanism-based management of cytokine storm syndromes

SW Canna, RQ Cron - Journal of Allergy and Clinical Immunology, 2020 - Elsevier
Since the first textbook devoted to cytokine storm syndromes (CSSs) was published in 2019,
the world has changed dramatically and the term's visibility has broadened. Herein, we …

Human oncoviruses and p53 tumor suppressor pathway deregulation at the origin of human cancers

ML Tornesello, C Annunziata, AL Tornesello… - Cancers, 2018 - mdpi.com
Viral oncogenesis is a multistep process largely depending on the complex interplay
between viruses and host factors. The oncoviruses are capable of subverting the cell …