Sepsis is defined as a life‐threatening disease involving multiple organ dysfunction caused
by dysregulated host responses to infection. To date, sepsis remains a dominant cause of …

The immune system has evolved to protect the host from the pathogens and allergens
surrounding their environment. The immune system develops in such a way to recognize …

Background Neuroinflammation-induced injury is intimately associated with poor prognosis
in patients with cerebral venous sinus thrombosis (CVST). The cyclic GMP-AMP synthase …

Adrenomedullin (ADM) exerts anti-oxidant, anti-inflammatory and anti-apoptotic effects in
Leydig cells. However, the role and mechanism of ADM in the pyroptosis of Leydig cells are …

Background Gut integrity is compromised in abdominal sepsis with increased cellular
apoptosis and altered barrier permeability. Intestinal epithelial cells (IEC) form a …

Sepsis is a systemic inflammatory disease with infection, and autophagy has been shown to
play an important role in sepsis. This review summarizes the main regulatory mechanisms of …

Innate immunity is the front-line defense against infectious microorganisms, including
viruses and bacteria. Type I interferons are pleiotropic cytokines that perform antiviral …

The cGAS-STING signaling plays an integral role in the host immune response, and the
abnormal activation of cGAS-STING is highly related to various autoimmune diseases …

Autophagy is the liver cell energy recycling system regulating a variety of homeostatic
mechanisms. Damaged organelles, lipids and proteins are degraded in the lysosomes and …

Emerging evidence suggests that pyroptosis is involved in sepsis. However, the role of
neutrophil pyroptosis in sepsis and the mechanisms remains elusive. We find that N …