Sodium–glucose co‐transporter 2 inhibitors as an early, first‐line therapy in patients with heart failure and reduced ejection fraction

D Tomasoni, GC Fonarow, M Adamo… - European journal of …, 2022 - Wiley Online Library
Sodium–glucose co‐transporter 2 (SGLT2) inhibitors have recently been recommended as a
foundational therapy for patients with heart failure (HF) and reduced ejection fraction …

Optimizing foundational therapies in patients with HFrEF: how do we translate these findings into clinical care?

A Sharma, S Verma, DL Bhatt, KA Connelly… - Basic to Translational …, 2022 - jacc.org
Given the high risk of adverse outcomes in patients with heart failure and reduced ejection
fraction (HFrEF), there is an urgent need for the initiation and titration of guideline-directed …

Reduction of dietary sodium to less than 100 mmol in heart failure (SODIUM-HF): an international, open-label, randomised, controlled trial

JA Ezekowitz, E Colin-Ramirez, H Ross, J Escobedo… - The Lancet, 2022 - thelancet.com
Background Dietary restriction of sodium has been suggested to prevent fluid overload and
adverse outcomes for patients with heart failure. We designed the Study of Dietary …

Insights into SGLT2 inhibitor treatment of diabetic cardiomyopathy: focus on the mechanisms

K Huang, X Luo, B Liao, G Li, J Feng - Cardiovascular Diabetology, 2023 - Springer
Among the complications of diabetes, cardiovascular events and cardiac insufficiency are
considered two of the most important causes of death. Experimental and clinical evidence …

Cardiorenal protection with SGLT2 inhibitors in patients with diabetes mellitus: from biomarkers to clinical outcomes in heart failure and diabetic kidney disease

H Liu, VS Sridhar, J Boulet, A Dharia, A Khan… - Metabolism, 2022 - Elsevier
Abstract Type 2 diabetes (T2D) is one of the most common causes of chronic kidney disease
(CKD) and cardiovascular (CV) disease. Until recently, glycemic and BP control were the …

Prevalence, outcomes and costs of a contemporary, multinational population with heart failure

A Norhammar, J Bodegard, M Vanderheyden, N Tangri… - Heart, 2023 - heart.bmj.com
Objective Digital healthcare systems could provide insights into the global prevalence of
heart failure (HF). We designed the CardioRenal and Metabolic disease (CaReMe) HF study …

A systematic review and meta-analysis of beta-blockers and renin–angiotensin system inhibitors for preventing left ventricular dysfunction due to anthracyclines or …

C Lewinter, TH Nielsen, LR Edfors, C Linde… - European heart …, 2022 - academic.oup.com
Aims Trastuzumab and anthracyclines, often used in the treatment of breast cancer, may
impair myocardial function, and reduce left ventricular ejection fraction (LVEF), potentially …

STICH3C: rationale and study protocol

SE Fremes, G Marquis-Gravel… - Circulation …, 2023 - Am Heart Assoc
BACKGROUND: Coronary artery bypass grafting (CABG) is the recommended mode of
revascularization in patients with ischemic left ventricular dysfunction (iLVSD) and …

European Society of Cardiology quality indicators for the care and outcomes of adults with heart failure. Developed by the Working Group for Heart Failure Quality …

S Aktaa, M Polovina, G Rosano, A Abdin… - European Journal of …, 2022 - Wiley Online Library
Aims To develop a suite of quality indicators (QIs) for the evaluation of the quality of care for
adults with heart failure (HF). Methods and results We followed the ESC methodology for QI …

Medical therapy during hospitalization for heart failure with reduced ejection fraction: the VICTORIA registry

SJ Greene, JA Ezekowitz, KJ Anstrom… - Journal of cardiac …, 2022 - Elsevier
Background For patients hospitalized for heart failure with reduced ejection fraction (HFrEF),
guidelines recommend optimization of medical therapy prior to discharge. The degree to …