Di (ethylhexyl) phthalate (DEHP) is a manufactured chemical commonly added to plastics: it
is a ubiquitous environmental contaminant to which humans are exposed through multiple …

Glucose consumption is generally increased in tumor cells to support tumor growth.
Interestingly, we report that glycogen accumulation is a key initiating oncogenic event during …

Chronic infection with hepatitis viruses represents the major causative factor for end-stage
liver diseases, including liver cirrhosis and primary liver cancer (hepatocellular carcinoma …

Simple Summary Hepatocellular carcinoma (HCC) is a highly incident and deadly malignant
neoplasia, and only a few anti-HCC drugs are currently available. Thus, the development of …

The metabolic pathway of de novo lipogenesis is frequently upregulated in human liver
tumours, and its upregulation is associated with poor prognosis. Blocking lipogenesis in …

Hepatocellular carcinoma (HCC) is the most predominant primary malignancy in the liver.
Genotoxic and genetic models have revealed that HCC cells are derived from hepatocytes …

To determine the possible role of the epigenetic mechanisms in carcinogenesis of the
hepatocellular carcinoma, we methylation-profiled the promoter CpG islands of twenty four …

Hepatocellular carcinoma (HCC) is the fifth most frequent human cancer and a fatal disease.
Therapies with pharmacological agents do not improve the prognosis of patients with …

Primary liver carcinomas in children and young adults are uncommon and poorly described.
We examined primary liver carcinomas in people younger than 30 years and performed …

N 6-methyladenosine (m 6 A), the most abundant internal modifier of mRNAs installed by the
methyltransferase 13 (METTL3) at the (G/A)(m 6 A) C motif, plays a critical role in the …