The activating receptor NKG2D is peculiar in its capability to bind to numerous and highly
diversified MHC class I-like self-molecules. These ligands are poorly expressed on normal …

Human cytomegalovirus (CMV), one of the eight herpesviruses that commonly infect
humans, is best known for its propensity to cause disease in immunocompromised patients …

A systematic quantitative analysis of temporal changes in host and viral proteins throughout
the course of a productive infection could provide dynamic insights into virus-host …

Since the development of vaccinia virus as a vaccine vector in 1984, the utility of numerous
viruses in vaccination strategies has been explored. In recent years, key improvements to …

MicroRNAs (miRNAs) have recently emerged as key posttranscriptional regulators of gene
expression in multicellular eukaryotes. It is increasingly clear that miRNAs of both viral and …

Human cytomegalovirus (HCMV) infection exerts broad effects on the immune system.
These include the differentiation and persistent expansion of a mature NK cell subset which …

Human cytomegalovirus (HCMV) infection induces both innate immune responses including
Natural Killer cells as well as adaptive humoral and cell mediated (CD4+ helper, CD8+ …

Although human cytomegalovirus (HCMV) is generally not regarded to be an oncogenic
virus, HCMV infection has been implicated in malignant diseases from different cancer …

Human cytomegalovirus (HCMV) infection is the most common cause of congenital viral
infections and a major source of morbidity and mortality after organ transplantation. NK cells …

In celebrating the 60th anniversary of the first isolation of human cytomegalovirus (HCMV),
we reflect on the merits and limitations of the viral strains currently being used to develop …