Aggressive leukemias arise in both children and adults as a result of rearrangements to the
mixed-lineage leukemia gene (MLL) located on chromosome 11q23. MLL encodes a large …

Leukemia in infants is rare but generates tremendous interest due to its aggressive clinical
presentation in a uniquely vulnerable host, its poor response to current therapies, and its …

PURPOSE Infant acute lymphoblastic leukemia (ALL) is characterized by KMT2A (MLL)
gene rearrangements and coexpression of myeloid markers. The Interfant-06 study …

Background Chromosomal abnormalities in childhood acute lymphoblastic leukaemia are
well established disease markers and indicators of outcomes. However, the long-term …

Cell competition is an emerging principle underlying selection for cellular fitness during
development and disease. Competition may be relevant for cancer, but an experimental link …

Infants with KMT2A‐rearranged acute lymphoblastic leukemia (KMT2A-r ALL) have a poor
prognosis. KMT2A-r ALL overexpresses FLT3, and the FLT3 inhibitor (FLT3i) lestaurtinib …

The outcome of children and adults with acute lymphoblastic leukemia is markedly different.
Since there is limited information on the distribution of clinico-biological variables in different …

Infant acute leukaemia is characterised by specific genetic rearrangements and a rapid
onset of disease shortly after birth. The vast majority of these cases bear rearranged MLL …

Although 90% of children with acute lymphoblastic leukemia (ALL) are now cured, the
prognosis for infant-ALL remains dismal. Infant-ALL is usually caused by a single genetic hit …

From the bestselling author, Barbara J. Bain, the new edition of this practical reference on
the principles of leukaemia diagnosis and classification has been fully updated, and …