Macrophages are cells of the innate immunity constituting the mononuclear phagocyte
system and endowed with remarkable different roles essential for defense mechanisms …

Mutationally corrupted cancer (stem) cells are the driving force of tumor development and
progression. Yet, these transformed cells cannot do it alone. Assemblages of ostensibly …

Cancer-induced immune responses affect tumour progression and therapeutic response. In
multiple murine models and clinical datasets, we identified large variations of neutrophils …

Macrophages are unique cells for origin, heterogeneity and plasticity. At steady state most of
macrophages are derived from fetal sources and maintained in adulthood through self …

Purpose Targeting tumor-infiltrating macrophages limits progression and improves
chemotherapeutic responses in pancreatic ductal adenocarcinoma (PDAC). Protease …

Transcription factors (TFs) control cell identity and function. How their activity is altered
during healthy aging is critical for an improved understanding of aging and disease risk, yet …

T helper (Th) 2-dependent type 2 immune pathways have been recognized as an important
driver for the development of fibrosis. Upon stimulation, activated Th2 immune cells and type …

The tumor microenvironment is a complex network of cells that support tumor progression
and malignancy. It has been demonstrated that tumor cells can educate the immune system …

Tumor-infiltrating neutrophils have been implicated in malignant development and
progression, but mechanisms are ill defined. Neutrophils produce a proliferation-inducing …

Oxygen availability affects cell differentiation, survival and function, with profound
consequences on tissue homeostasis, inflammation and immunity. A gradient of oxygen …