[PDF][PDF] Impairing L-threonine catabolism promotes healthspan through methylglyoxal-mediated proteohormesis
M Ravichandran, S Priebe, G Grigolon, L Rozanov… - Cell metabolism, 2018 - cell.com
Whether and how regulation of genes and pathways contributes to physiological aging is
topic of intense scientific debate. By performing an RNA expression-based screen for genes …
topic of intense scientific debate. By performing an RNA expression-based screen for genes …
Age-and stage-dependent glyoxalase I expression and its activity in normal and Alzheimer's disease brains
B Kuhla, K Boeck, A Schmidt, V Ogunlade, T Arendt… - Neurobiology of …, 2007 - Elsevier
The reaction of lysine and arginine residues of proteins with 1, 2-dicarbonyl compounds
result in the formation of advanced glycation end products (AGEs). Accumulation of AGEs is …
result in the formation of advanced glycation end products (AGEs). Accumulation of AGEs is …
Methylglyoxal causes strong weakening of detoxifying capacity and apoptotic cell death in rat hippocampal neurons
S Di Loreto, V Zimmitti, P Sebastiani, C Cervelli… - The international journal …, 2008 - Elsevier
The hippocampus is known to play a crucial role in learning and memory. Recent data from
literature show that cognitive problems, common to aged or diabetic patients, may be related …
literature show that cognitive problems, common to aged or diabetic patients, may be related …
Evidence that carbonyl stress by methylglyoxal exposure induces DNA damage and spindle aberrations, affects mitochondrial integrity in mammalian oocytes and …
C Tatone, T Heizenrieder, G Di Emidio… - Human …, 2011 - academic.oup.com
BACKGROUND Highly reactive carbonyl compounds formed during glycolysis, such as
methylglyoxal (MG), can lead to the formation of 'advanced glycation end products'(AGE) …
methylglyoxal (MG), can lead to the formation of 'advanced glycation end products'(AGE) …
Methylglyoxal induces oxidative stress-dependent cell injury and up-regulation of interleukin-1β and nerve growth factor in cultured hippocampal neuronal cells
S Di Loreto, V Caracciolo, S Colafarina, P Sebastiani… - Brain research, 2004 - Elsevier
Methylglyoxal (MG) is one of the most powerful glycating agents of proteins and other
important cellular components and has been shown to be toxic to cultured cells. Under …
important cellular components and has been shown to be toxic to cultured cells. Under …
Age-dependent changes of glyoxalase I expression in human brain
B Kuhla, K Boeck, HJ Lüth, A Schmidt, B Weigle… - Neurobiology of …, 2006 - Elsevier
Increased modification and crosslinking of proteins by advanced glycation end products
(AGEs) is a characteristic feature of aging, and contributes to the formation of many of the …
(AGEs) is a characteristic feature of aging, and contributes to the formation of many of the …
Endothelial cells from umbilical cord of women affected by gestational diabetes: A suitable in vitro model to study mechanisms of early vascular senescence in …
P Di Tomo, N Alessio, S Falone… - The FASEB …, 2021 - Wiley Online Library
Human umbilical cord endothelial cells (HUVECs) obtained from women affected by
gestational diabetes (GD‐HUVECs) display durable pro‐atherogenic modifications and …
gestational diabetes (GD‐HUVECs) display durable pro‐atherogenic modifications and …
Nanotechnology: toxicologic pathology
AF Hubbs, LM Sargent, DW Porter… - Toxicologic …, 2013 - journals.sagepub.com
Nanotechnology involves technology, science, and engineering in dimensions less than 100
nm. A virtually infinite number of potential nanoscale products can be produced from many …
nm. A virtually infinite number of potential nanoscale products can be produced from many …
Long-lasting changes in DNA methylation following short-term hypoxic exposure in primary hippocampal neuronal cultures
I Hartley, FF Elkhoury, J Heon Shin, B Xie, X Gu, Y Gao… - PloS one, 2013 - journals.plos.org
While the effects of hypoxia on gene expression have been investigated in the CNS to some
extent, we currently do not know what role epigenetics plays in the transcription of many …
extent, we currently do not know what role epigenetics plays in the transcription of many …
A novel mechanism of methylglyoxal cytotoxicity in prostate cancer cells
C Antognelli, L Mezzasoma, K Fettucciari… - The international journal …, 2013 - Elsevier
Methylglyoxal is one of the most powerful glycating agents of proteins and other important
cellular components and has been shown to be toxic to cultured cells. Methylglyoxal …
cellular components and has been shown to be toxic to cultured cells. Methylglyoxal …