Amyloid-β and tau are the two hallmark proteins in Alzheimer's disease. Although both
amyloid-β and tau have been extensively studied individually with regard to their separate …

Synaptic loss is the major neurobiological substrate of cognitive dysfunction in Alzheimer's
disease (AD). Synaptic failure is an early event in the pathogenesis that is clearly detectable …

Accumulating evidence indicates that p38 mitogen-activated protein kinase (MAPK) could
play more than one role in Alzheimer's disease (AD) pathophysiology and that patients …

Background: Alzheimer's disease (AD), the most common form of dementia, is a progressive
neurodegenerative disorder with interrelated molecular, physiological, anatomical …

The detection of myelin disruptions in Alzheimer's disease (AD)–affected brain raises the
possibility that oligodendrocytes undergo pathophysiological assault over the protracted …

Alzheimer's disease (AD) is characterized by progressive, age-dependent degeneration of
neurons in the central nervous system. A large body of evidence indicates that neurons …

Tau, a major microtubule‐associated protein in brain, forms abnormal fibers in Alzheimer's
disease and several other neurodegenerative diseases. Tau is highly soluble and adopts a …

Axon degeneration is an active, tightly controlled and versatile process of axon segment self-
destruction. Although not involving cell death, it resembles apoptosis in its logics. It involves …

Development of a comprehensive therapeutic treatment for the neurodegenerative
Alzheimer's disease (AD) is limited by our understanding of the underlying biochemical …

The pathology of Alzheimer's disease (AD) is characterized by amyloid plaques (aggregates
of amyloid-β (Aβ)) and neurofibrillary tangles (aggregates of tau) and is accompanied by …