The aging process worsens the human body functions at multiple levels, thus causing its
gradual decrease to resist stress, damage, and disease. Besides changes in gene …

Longevity and healthy aging are among the most complex phenotypes studied to date. The
heritability of age at death in adulthood is approximately 25%. Studies of exceptionally long …

Objective: Major depressive disorder is associated with an increased risk of mortality and
aging-related diseases. The authors examined whether major depression is associated with …

Aging is an important risk factor for several human diseases such as cancer, cardiovascular
disease and neurodegenerative disorders, resulting from a combination of genetic and …

Biological measures of aging are important for understanding the health of an aging
population, with epigenetics particularly promising. Previous studies found that tumor tissue …

Recent statistics indicate that the human population is ageing rapidly. Healthy, but also
diseased, elderly people are increasing. This trend is particularly evident in Western …

DNA methylation is currently the most promising molecular marker for monitoring aging and
predicting life expectancy. However, the mechanisms underlying age-related DNA …

Activated macrophages play a central role in both the development and resolution of
inflammation. These immune cells need to be functional in harmful conditions with high …

Longevity as a complex life-history trait shares an ontogenetic relationship with other
quantitative traits and varies among individuals, families and populations. Heritability …

Life expectancy of humans has increased continuously up to the present days, but their
health status (healthspan) was not enhanced by similar extent. To decrease enormous …