5-Fluorouracil remains a foundational component of chemotherapy for solid tumour
malignancies. While considered a generally safe and effective chemotherapeutic, 5 …

While there have been rapid advances in developing new and more targeted drugs to treat
cancer, much less progress has been made in individualizing dosing. Even though the …

The purpose of this guideline is to provide information for the interpretation of clinical
dihydropyrimidine dehydrogenase (DPYD) genotype tests so that the results can be used to …

Introduction: Body surface area dosing of chemotherapeutic agents is based on limited
scientific data, and often results in unpredictable plasma drug levels. Cross-sectional …

Cytotoxic drugs are highly efficacious and also have low therapeutic index. A great degree
of caution needs to be exercised in their usage. To optimize the efficacy these drugs need to …

Pharmacogenomics is based on the understanding of the individual differences in drug use,
the response to drug therapy (efficacy and toxicity), and the mechanisms underlying variable …

Highlights•A variety of computational methods and tools are used in QSP and QST. They
show different degrees of maturity.•PBPK models are well established and applied in a wide …

Aims 5-FU is used as the main backbone of chemotherapy regimens for patients with
colorectal and other gastrointestinal cancers. Despite development of new strategies that …

fluorouracil (5-FU) is a chemotherapeutic agent that has been used for the treatment of a
variety of malignancies since its initial introduction to the clinic in 1957. Owing to its short …

Hot melt extrusion (HME), a technology which mixing the advantages of solid dispersion
technology and mechanical preparation, is accepted in varied applications in …