Novel insights into the interaction between N6‐methyladenosine methylation and noncoding RNAs in musculoskeletal disorders

J Han, H Kong, X Wang, X Zhang - Cell Proliferation, 2022 - Wiley Online Library
Background Musculoskeletal disorder (MSD) are a class of inflammatory and degener‐ative
diseases, but the precise molecular mechanisms are still poorly understood. Noncoding …

Crosstalk between m6A regulators and mRNA during cancer progression

X Niu, Y Yang, Y Ren, S Zhou, Q Mao, Y Wang - Oncogene, 2022 - nature.com
Abstract m6A modification, the most abundant and widespread RNA modification, is present
and involved in the occurrence and development of various cancers. To date, most studies …

[HTML][HTML] Inhibition of ALKBH5 attenuates I/R-induced renal injury in male mice by promoting Ccl28 m6A modification and increasing Treg recruitment

J Chen, C Xu, K Yang, R Gao, Y Cao, L Liang… - Nature …, 2023 - nature.com
Ischemia reperfusion injury (IRI) is a common cause of acute kidney injury (AKI). The role of
N6-methyladenosine (m6A) modification in AKI remains unclear. Here, we characterize the …

M6AREG: m6A-centered regulation of disease development and drug response

S Liu, L Chen, Y Zhang, Y Zhou, Y He… - Nucleic Acids …, 2023 - academic.oup.com
As the most prevalent internal modification in eukaryotic RNAs, N 6-methyladenosine (m6A)
has been discovered to play an essential role in cellular proliferation, metabolic …

METTL16 promotes osteosarcoma progression by downregulating VPS33B in an m6A‐dependent manner

J Cheng, Z Xu, W Tan, J He, B Pan… - Journal of Cellular …, 2024 - Wiley Online Library
Abstract N6‐methyladenosine (m6A) is one of the main epitranscriptomic modifications that
accelerates the progression of malignant tumors by modifying RNA. Methyltransferase‐like …

ZBTB7C m6A modification incurred by METTL3 aberration promotes osteosarcoma progression

X An, W Wu, L Yang, J Dong, B Liu, J Guo, J Chen… - Translational …, 2023 - Elsevier
Abstract Aberrant N6-methyladenosine (m6A) modification of mRNAs contributes
significantly to the epigenetic tumorigenesis, however, its precise role and the key targets in …

Crosstalk between gut microbiota and RNA N6-methyladenosine modification in cancer

H Su, H Cheung, HCH Lau, H Chen… - FEMS microbiology …, 2023 - academic.oup.com
The gut microbiota plays a crucial role in regulating various host metabolic, immune, and
neuroendocrine functions, and has a significant impact on human health. Several lines of …

[HTML][HTML] Novel insights into the interplay between m6A modification and programmed cell death in cancer

J Chen, M Ye, J Bai, C Hu, F Lu, D Gu… - International journal of …, 2023 - ncbi.nlm.nih.gov
Abstract N6-methyladenosine (m6A) methylation, the most prevalent and abundant RNA
modification in eukaryotes, has recently become a hot research topic. Several studies have …

N6-methyladenosine (m6A) modification in osteosarcoma: expression, function and interaction with noncoding RNAs–an updated review

Y Zhang, Y Xu, Y Bao, Y Luo, G Qiu, M He, J Lu, J Xu… - Epigenetics, 2023 - Taylor & Francis
Osteosarcoma, originating from primitive bone-forming mesenchymal cells, is the most
common malignant bone tumour among children and adolescents. N6-methyladenosine …

RNA demethylase ALKBH5 promotes colorectal cancer progression by posttranscriptional activation of RAB5A in an m6A‐YTHDF2‐dependent manner

D Shen, J Lin, Y Xie, Z Zhuang, G Xu… - Clinical and …, 2023 - Wiley Online Library
Abstract Background N6‐methyladenosine (m6A) modification is an emerging epigenetic
regulatory mechanism in tumourigenesis. Considering that AlkB homolog 5 (ALKBH5) is a …