Adipose tissues are dynamic tissues that play crucial physiological roles in maintaining
health and homeostasis. Although white adipose tissue and brown adipose tissue are …

Alongside the liver, white adipose tissue (WAT) is critical in regulating systemic energy
homeostasis. Although each organ has its specialised functions, they must work …

The peroxisome proliferator-activated receptors (PPAR-α, PPAR-β/δ, and PPAR-γ) are
members of the nuclear receptor super-family, acting as ligand-inducible transcription …

Super-enhancers are large clusters of transcriptional enhancers that drive expression of
genes that define cell identity. Improved understanding of the roles that super-enhancers …

In the modern era of advanced technologies, rapid and accurate analyses are needed, both
for scientific research and for industrial applications. For this reason, the Surface Plasmon …

Peroxisome proliferator-activated receptors are expressed in many tissues, including
adipocytes, hepatocytes, muscles and endothelial cells; however, the affinity depends on the …

Peroxisome proliferator-activated receptor gamma (PPARγ) has been the focus of intense
research because ligands for this receptor have emerged as potent insulin sensitizers used …

Abstract Thiazolidinediones (TZDs) or Glitazones are an important class of insulin
sensitizers used in the treatment of Type 2 diabetes mellitus (T2DM). TZDs were reported for …

Our understanding of the role of the vascular endothelium has evolved over the past 2
decades, with the recognition that it is a dynamically regulated organ and that it plays a …

Agonists of the nuclear receptor PPARγ are therapeutically used to combat hyperglycaemia
associated with the metabolic syndrome and type 2 diabetes. In spite of being effective in …