Diabetic retinopathy as the leading cause of blindness and early predictor of cascading complications—risks and mitigation

M Kropp, O Golubnitschaja, A Mazurakova… - Epma Journal, 2023 - Springer
Proliferative diabetic retinopathy (PDR) the sequel of diabetic retinopathy (DR), a frequent
complication of diabetes mellitus (DM), is the leading cause of blindness in the working-age …

Flavonoids as anticancer agents

DM Kopustinskiene, V Jakstas, A Savickas… - Nutrients, 2020 - mdpi.com
Flavonoids are polyphenolic compounds subdivided into 6 groups: isoflavonoids,
flavanones, flavanols, flavonols, flavones and anthocyanidins found in a variety of plants …

Naringenin: A potential flavonoid phytochemical for cancer therapy

M Motallebi, M Bhia, HF Rajani, I Bhia, H Tabarraei… - Life Sciences, 2022 - Elsevier
Naringenin is an important phytochemical which belongs to the flavanone group of
polyphenols, and is found mainly in citrus fruits like grapefruits and others such as tomatoes …

Naringin and naringenin: Their mechanisms of action and the potential anticancer activities

J Stabrauskiene, DM Kopustinskiene, R Lazauskas… - Biomedicines, 2022 - mdpi.com
Naringin and naringenin are the main bioactive polyphenols in citrus fruits, the consumption
of which is beneficial for human health and has been practiced since ancient times …

Extraction of flavonoids from natural sources using modern techniques

JO Chaves, MCA De Souza, LC Da Silva… - Frontiers in …, 2020 - frontiersin.org
Flavonoids are one of the main groups of polyphenols found in natural products. Traditional
flavonoid extraction techniques are being replaced by advanced techniques to reduce …

Rutin: A flavonoid as an effective sensitizer for anticancer therapy; insights into multifaceted mechanisms and applicability for combination therapy

A Satari, S Ghasemi, S Habtemariam… - Evidence‐Based …, 2021 - Wiley Online Library
Rutin is a unique antioxidant flavonoid that is mainly found in fruit, vegetables, cereals, and
many other plant‐based human diets. This review aims to highlight the in vitro anticancer …

Flavonoids and their anti-diabetic effects: Cellular mechanisms and effects to improve blood sugar levels

RK Al-Ishaq, M Abotaleb, P Kubatka, K Kajo… - Biomolecules, 2019 - mdpi.com
Diabetes mellitus (DM) is a prevailing global health metabolic disorder, with an alarming
incidence rate and a huge burden on health care providers. DM is characterized by the …

[HTML][HTML] Flavonoids against the SARS-CoV-2 induced inflammatory storm

A Liskova, M Samec, L Koklesova, SM Samuel… - Biomedicine & …, 2021 - Elsevier
The disease severity of COVID-19, especially in the elderly and patients with co-morbidities,
is characterized by hypercytokinemia, an exaggerated immune response associated with an …

Anti-cancer potential of cannabinoids, terpenes, and flavonoids present in cannabis

AM Tomko, EG Whynot, LD Ellis, DJ Dupré - Cancers, 2020 - mdpi.com
In recent years, and even more since its legalization in several jurisdictions, cannabis and
the endocannabinoid system have received an increasing amount of interest related to their …

Dietary polyphenols in chemoprevention and synergistic effect in cancer: Clinical evidences and molecular mechanisms of action

S Patra, B Pradhan, R Nayak, C Behera, S Das… - Phytomedicine, 2021 - Elsevier
Background Epidemiological studies has revealed that a diet rich in fruits and vegetables
could lower the risk of certain cancers. In this setting, natural polyphenols are potent …