SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC)

AD Proal, MB VanElzakker, S Aleman, K Bach… - Nature …, 2023 - nature.com
Millions of people are suffering from Long COVID or post-acute sequelae of COVID-19
(PASC). Several biological factors have emerged as potential drivers of PASC pathology …

Use of cardiopulmonary exercise testing to evaluate long COVID-19 symptoms in adults: a systematic review and meta-analysis

MS Durstenfeld, K Sun, P Tahir, MJ Peluso… - JAMA network …, 2022 - jamanetwork.com
Importance Reduced exercise capacity is commonly reported among individuals with COVID-
19 symptoms more than 3 months after SARS-CoV-2 infection (long COVID-19 [LC]) …

[HTML][HTML] Chronic viral coinfections differentially affect the likelihood of developing long COVID

MJ Peluso, TM Deveau, SE Munter… - The Journal of …, 2023 - Am Soc Clin Investig
BACKGROUND The presence and reactivation of chronic viral infections, such as EBV,
CMV, and HIV, have been proposed as potential contributors to long COVID (LC), but …

[PDF][PDF] Serotonin reduction in post-acute sequelae of viral infection

AC Wong, AS Devason, IC Umana, TO Cox… - Cell, 2023 - cell.com
Post-acute sequelae of COVID-19 (PASC," Long COVID") pose a significant global health
challenge. The pathophysiology is unknown, and no effective treatments have been found to …

SARS‐CoV‐2 and mitochondrial proteins in neural‐derived exosomes of COVID‐19

MJ Peluso, SG Deeks, M Mustapic… - Annals of …, 2022 - Wiley Online Library
Objective As SARS‐CoV‐2 is known to invade neural cell mitochondria, a plasma system for
quantifying central nervous system proteins in living humans was used to investigate …

Plasma markers of neurologic injury and inflammation in people with self-reported neurologic postacute sequelae of SARS-CoV-2 infection

MJ Peluso, HM Sans, CA Forman… - Neurology …, 2022 - AAN Enterprises
Background and Objectives The biologic mechanisms underlying neurologic postacute
sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …

Evolution of neurologic symptoms in non‐hospitalized COVID‐19 “long haulers”

ST Ali, AK Kang, TR Patel, JR Clark… - Annals of clinical …, 2022 - Wiley Online Library
Objective We characterized the evolution of neurologic symptoms and self‐perceived
recovery of non‐hospitalized COVID‐19 “long haulers” 6–9 months after their initial Neuro …

[HTML][HTML] Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2

K Yin, MJ Peluso, X Luo, R Thomas, MG Shin… - Nature …, 2024 - nature.com
Long COVID (LC) occurs after at least 10% of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infections, yet its etiology remains poorly understood. We used …

[HTML][HTML] Markers of fungal translocation are elevated during post-acute sequelae of SARS-CoV-2 and induce NF-κB signaling

LB Giron, MJ Peluso, J Ding, G Kenny, NF Zilberstein… - JCI insight, 2022 - ncbi.nlm.nih.gov
Long COVID, a type of post-acute sequelae of SARS-CoV-2 (PASC), has been associated
with sustained elevated levels of immune activation and inflammation. However, the …

Factors associated with long COVID symptoms in an online cohort study

MS Durstenfeld, MJ Peluso, ND Peyser… - Open forum …, 2023 - academic.oup.com
Background Few prospective studies of Long COVID risk factors have been conducted. The
purpose of this study was to determine whether sociodemographic factors, lifestyle, or …