Noroviruses are small, positive-sense RNA viruses within the family Caliciviridae, and are
now accepted widely as a major cause of acute gastroenteritis in both developed and …

Human noroviruses are recognised as the major global cause of viral gastroenteritis. Here,
we provide an overview of notable advances in norovirus research and provide a short …

Small RNA viruses have evolved many mechanisms to increase the capacity of their short
genomes. Here we describe the identification and characterization of a novel open reading …

Cathepsins encompass a family of lysosomal proteases that mediate protein degradation
and turnover. Although mainly localized in the endolysosomal compartment, cathepsins are …

Non-enveloped viruses require cell lysis to release new virions from infected cells,
suggesting that these viruses require mechanisms to induce cell death. Noroviruses are one …

Human noroviruses in the family Caliciviridae are a major cause of epidemic gastroenteritis.
They are responsible for at least 95% of viral outbreaks and over 50% of all outbreaks …

Background Infection may trigger clinically overt mucosal inflammation in patients with
predisposition for inflammatory bowel disease. However, the impact of particular …

Norovirus infection is the leading cause of food-borne gastroenteritis worldwide, being
responsible for over 200,000 deaths annually. Studies with murine norovirus (MNV) showed …

Lysosomes are acidic organelles that mediate the degradation and recycling of cellular
waste materials. Damage to lysosomes can cause lysosomal membrane permeabilization …

A long-standing paradigm in virology was that non-enveloped viruses induce cell lysis to
release progeny virions. However, emerging evidence indicates that some non-enveloped …